A Clinical Study of Epidural Pentazocine in Comparison with Epidural Tramadol for Postoperative Analgesia
Objectives To evaluate and compare the efficacy of epidurally administered Tramadol Hydrochloride and Pentazocine Lactate in providing post operative pain relief for lower abdominal and lower limb surgeries. To compare the side effects between epidural tramadol and pentazocine. Design A prospective randomized study Methodology The study population consisted of 100 patients aged between 18-65 years posted for various elective lower abdominal and lower limb surgeries requiring neuraxial anaesthesia at M.V.J.Medical College & Research Hospital, Hoskote, Bangalore. The study population was randomly divided into 2 groups with 50 patients in each sub group. 1. Group T: Administered 50mg Tramadol, diluted to 10ml with Normal saline, epidurally (n= 50) 2. Group P: Administered 0.3mg/kg Pentazocine, diluted to 10ml with Normal saline, epidurally (n = 50) Patient was monitored on various parameters including duration of action, hemodynamic variables, and side effects Results In group administered 50mg Tramadol epidurally, the mean time to onset of analgesia was 4.36±2.23 mins and the mean time to onset of analgesia in the group administered pentazocine was 4.84±2.24 mins, with a p value of 0.286, which is not considered significant. Ix In tramadol group, the analgesic period averaged 7 hours 20 minutes, while the duration of analgesia in group P averaged 6 hours 43 minutes, with a p value of 0.475, which is not considered significant. It was also observed that 0.3mg/kg of pentazocine produced marginally higher incidence of bradycardia, dizziness, drowsiness and sedation as compared to 50mg of tramadol on epidural administration. Conclusion With these results, we conclude that epidural tramadol 50mg gives longer lasting and more profound analgesia with lesser side effects when compared to 0.3mg/kg of pentazocine.
B Narasimha Reddy, Madhu R, Jithin Chandra Bose, Yadhuraj MK, Faizana Mohammed and Supriya Pawar