Design of Orodispersible Tablets of Losartan Potassium Using Novel Co-Processed Superdisintegrants
In this new era of novel drug delivery systems, formulation research is oriented towards increasing the efficacy of existing drug molecule through these novel concepts of drug delivery. Losartan potassium is widely used as an antihypertensive drug, which is a potent drug candidate for developing in to Orodispersible tablets (ODTs). It has low bioavailability due to first pass metabolism. Hence the main objective of the study was to formulate fast dissolving tablets of Losartan potassium to achieve a better dissolution rate and further improving the bioavailability of the drug. Orodispersible tablets of Losartan potassium were formulated by using different concentration of superdisintegrants like sodium starch Glycolate, Crospovidone individually, physically mixed and co-processed and all the batches were prepared by direct compression using standard round faced punch on a sixteen station rotary (Cadmach, Ahmadabad) tablet punching machine. Disintegration time and drug release were taken as the basis to optimize the orodispersible tablet. All the tablets were Prepared & evaluated for various parameters like hardness, weight variation, friability, thickness, disintegration time wetting time and dissolution time. Among all the formulations containing 5% w/w of co-processed superdisintegrant (1:1 mixture of CP and SSG) was found to be shown faster and high drug dissolution.
V Sai Kishore, B Tejeswara Rao, Y Sai Kumar, and D Nagasen