Effects of Ethanolic Extract of Unripe fruit of Aegle marmelos(Bael) on Intestinal Fluid Transport and Motility in Rats.
The present investigation was undertaken to study the effect of alcoholic extract of Aegle marmelos fruit (AME) on castor oil induced intraluminal fluid, electrolyte accumulation in jejunum and intestinal motility in rats. Enteropooling method was used to measure movement of fluid and electrolyte from 2ml of tyrode solution placed in jejunum (20 cm) of anesthetized rats in 30 min period. Intestinal transit of charcoal meal is used to assess intestinal motility in rats. In control rats there was net absorption of fluid and electrolyte (Na+,Cl-), whereas, fluid and electrolyte accumulation was observed in castor oil group compared to control. Pretreatment of rats with higher dose of AME (800 mg/kg,p.o.) significantly prevented castor oil induced fluid and electrolyte accumulation, whereas the lower dose (400 mg/kg) had no effect. Both doses of AME (400 and 800 mg/kg) significantly reduced the intestinal transit of charcoal meal compared to control rats. Our results provide experimental evidence and rationale for antidiarrhoeal effects of Aegle marmelos fruits.
Manjunath V Jali, Nirmala P, Annamalai AR, and Basavaraj KM