Pharmacological and Histochemical Screening for Hair Growth-Promoting Activity of Daucus carota Herbal Gel.
Daucus carota L. (Carrot) (Apiaceae) is used in the traditional medicine for the treatment of variety of ailments. It has been used in salads, vegetable. In the titled research pet.ether and aqueous extract of Daucus carota was initially tested for the type of phytoconstitutents and then the extract was standardized for the marker compound. Animal studies were carried out by application of standardized extract in gel formulation to the shaved dorsal skin of albino rats. Histomorphometric analysis was employed to study induction of the hair follicle cycle. To determine the effect of extract on the telogen to anagen transition, the protein expression levels of β-catenin in hair follicles were determined by immunohistochemistry. We observed that pet ether Daucus carota extract promoted hair growth by inducing the anagen phase. Specifically the histomorphometric analysis data indicates that topical application of the extract in gel form induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to control and 1% minoxidil treated group. Results also exposed the increase in both the numbers and size of hair follicles of the extract treated group. Moreover, the immunehistochemical analysis reveals earlier induction of β-catenin in hair follicles of the extract-treated group, compared to the control group.
Namrta Shukla, Sridevi G and Gopkumar P