Synthesis of Pharmaceutically Important 1,3,4-Thiadiazole Derivatives as Antimicrobials.
Thiosemicarbazide of phenyl hydrazine on cyclization with different aromatic carboxylic acid in POCl3 gives 2-(substituted phenyl)-5- (2-phenylhydrazinyl)-1,3,4-thiadiazole. 1,3,4-thiadiazole constitute a unique class of nitrogen and sulphur containing five member heterocycle. During the last years considerable evidence has also accumulated to demonstrate the efficacy of 1,3,4-thiadiazole including antifungal , anti cancer, anticonvulsant , insecticidal, anti bacterial, anti inflammatory and other biological effects. All the compounds were characterized on the basis of IR and 1HNMR spectral data & were screened for antimicrobial activity.
Nitin Deshmukh, Gopkumar P, and Sujit Pillai.