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Volume 6 Research & Reviews: Journal of Material Sciences Advanced Materials 2018
September 19-21, 2018
September 19-21, 2018 Tokyo, Japan
22nd International Conference on
Advanced Materials and Nanotechnology
Jong-Min Lim, Res. Rev. J Mat. Sci. 2018, Volume 6
DOI: 10.4172/2321-6212-C4-023
Large-scale synthesis of functional nanoparticles using a coaxial turbulent jet mixer
Jong-Min Lim
Soonchunhyang University, Republic of Korea
Nanoparticles are widely studied for the diagnosis and therapy of various diseases. Microfluidic platforms are adopted
for the synthesis of various nanoparticles due to controllability and reproducibility in their physicochemical properties.
However, there are several intrinsic limitations in conventional Polydimethylsiloxane (PDMS) microfluidic systems for the
synthesis of nanoparticles. In this work, we report a coaxial turbulent jet mixer capable of synthesizing various types of
functional nanoparticles with high-throughput manner, while maintaining the controllability and reproducibility of PDMS
microfluidic systems. In the coaxial turbulent jet mixer, the inner flow stream containing rawmaterials mixed with outer stream
of non-solvent by turbulent flow for self-assembly of nanoparticles by rapid solvent exchange method called nanoprecipitation.
Two dimensionless parameters, flow velocity ratio and Reynolds number (Re), were used to classify the mixing behavior
into flow regimes. Operating in the turbulence jet regime, the mixing time could be precisely controlled by changing the
Re. Nanoparticles obtained using the coaxial turbulent jet mixer at high Re (i.e., rapid mixing) were more homogeneous
and smaller than those synthesized by bulk mixing, because the mixing time scale is more controllable and shorter than the
characteristic aggregation time scale. Since the coaxial turbulent jet mixer is compatible with various organic solvents, it is
versatile system where various types of nanoparticles. Various functional agents could be loaded in the nanoparticles during
the nanoprecipitation. The coaxial turbulent jet mixer can be used to make functional nanoparticles with high-throughput and
reproducible manner suitable for clinical studies and mass production.
Biography
Jong-Min Lim has completed his PhD degree in Chemical and Biomolecular Engineering from KAIST. After Post-doctoral studies from KAIST, Harvard Medical
School and MIT, he has worked in Samsung Electronics as a Principal Engineer. Currently, he is an Assistant Professor in Department of Chemical Engineering,
Soonchunhyang University. He has published more than 25 papers.