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June 28-29, 2019 | Oslo, Norway
Volume 08
Journal of Medical and Health Sciences | ISSN : 2319-
Breast Pathology and Cancer, Gynecology and Obstetrics Pathology, Palliativecare and Gerontology 2019
Joint Event
Breast Pathology & Cancer
Palliativecare & Gerontology
Gynecology and Obstetrics Pathology
A randomized controlled clinical trial on comparing the efficacy of soy isoflavones and
evening primrose oil in improving the symptoms of menopausal Filipino women seen at the
outpatient department of a Tertiary Medical Center in Quezon City
Maria Kathrina S B Timbol, Anna Belen Ignacio-Alensuela
and
Lylah D Reyes
Far Eastern University-Dr Nicanor Reyes Medical Foundation, Philippines
Background:
Menopausal hormonal therapy (MHT) remains the treatment of choice in relieving menopausal
symptoms. However, some women are at risk to developing serious effects with its use. Current alternatives
to relieve menopausal symptoms include soy isoflavones and evening primrose oil (EPO). But the available
studies conducted to evaluate their efficacy remains insufficient.
Objective:
The main objective of the present study is to compare the efficacy of soy isoflavones and EPO
in improving the symptoms of menopausal Filipino women seen at the outpatient department of a Tertiary
Medical Center in Quezon City.
Methodology:
This is an open-label randomized controlled clinical trial involving 180 naturally menopause
women randomized into two groups. There were 91 women who received 60 mg isoflavones and 89 who
took EPO 1,000 mg per day for six months. Symptomatology was assessed using the menopause rating scale
(MRS) at baseline, first, third and six months of treatment.
Results:
The mean age of the participants is 48 years old with a mean gravidity and parity of two and average
of one to four years of menopause. However, after three months of treatment, the isoflavone group showed a
significantly lower MRS score for the somatic symptoms as compared to those in the EPO group (7.0 versus
8.0, p=0.03). The MRS score for somatic remained significantly lower for those who took isoflavones as
compared EPO up to the 6th month of treatment (6.89 versus 7.92; p=0.02). In the same period, a significantly
lower score for the urogenital symptoms was also observed among women in the isoflavones arm (6.73 versus
7.60; p=0.01). But when categorized according to severity of symptoms, there was no significant difference
in the proportion of participants distributed per category between the two treatment arms.
Conclusion:
Soy isoflavones at 60mg/day was found to be more effective than EPO in improving somatic
and urogenital symptoms.
RRJMHS 2019, Volume 08