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November 13-15, 2017 | Las Vegas, USA
14th International Conference and Exhibition on
Materials Science and Engineering
RRJOMS | Volume 5 | Issue 7 | November, 2017
Random poly (ɛ-Caprolactone-L-Alanine) by direct melt copolymerization
Christelle Delaite1 and Slim Salhi2
1Université de Haute Alsace, Mulhouse, France
2Université de Sfax, Tunisie
During recent years, many research works have been directed to the preparation of biodegradable and biocompatible polymeric
materials with controlled chemical, physical, and biological properties for a wide range of biomedical applications in the fields of
surgical implants, surgical sutures, artificial skin, resorbable bone plates, tissue engineering scaffolds and carrier system for controlled
release of drogue and genes. Various synthetic strategies can be used for the preparation of amino acid-based poly (ester amide) s
(AA-PEAs) presenting block, alternating or random structures. Random PEAs can be prepared by simple procedures that do not
require the use of solvents or expensive monomers like α-amino acid N-carboxyanhydrides (NCAs). Some studies have reported
the synthesis of Random AA–PEAs by the direct reaction of amino acids with cyclic esters or by the direct bulk polycondensation
of amino acids and α-hydroxyacids. The aim of the present work is to study the synthesis and properties of random polyesteramides
prepared by the bulk copolymerization of inexpensive ɛ-caprolactone and L-alanine, using a simple one-step procedure. A series of
randompolyesteramideswithin a range of molar composition from 90/10 to 50/50 were synthesized by a direct melt polycondensation.
Their structure was fully characterized by FTIR and NMR spectroscopy. The resulting copolymers are completely amorphous with the
exception of PEA-90/10 which possess a semi-crystalline structure. These PEAs present increasing glass transition temperatures at
increasing L-alanine contents, and exhibit fairly good thermal stability with 10 % mass loss temperatures reaching 315°C.
Biography
Christelle Delaite is professor at the Université de Haute-Alsace, Laboratoire de Photochimie et d'Ingénierie Macromoléculaires (LPIM), Mulhouse, France. Her research
and teaching activities focuse on macromolecular synthesis, (nano)composites elaboration and in the evaluation of the relationship between structure and physical prop-
erties of (co)polymers. This work is a collaboration with Slim Salhi who is assistant professor at the Université of Sfax, Laboratoire de Chimie Appliquée, Sfax-Tunisie. His
research and teaching activities focuse on macromolecular synthesis, elaboration and characterization of amino-acid biosourced copolymers and chemical modification of
polymers.
Christelle Delaite et al., Res. Rev. J Mat. Sci. 2017, 5:7
DOI: 10.4172/2321-6212-C1-012