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Pathology 2018 Research & Reviews: Journal of Medical and Health Sciences
ISSN: 2319-9865 Page 57
October 08-09, 2018
Edinburgh, Scotland
17th International Conference on
Pathology & Cancer
Epidemiology
To investigate whether there is any change in PTEN gene
expression profile and tumor aggressiveness in endometrial
carcinoma patients who lived in (DU) polluted area with those
patients who lived in unpolluted area. An elevation in the PTEN
gene expression profile was recorded in patients who lived in
(DU) polluted area in comparison with the patients who have had
the tumor though they lived in unpolluted area. The increase in
gene expression was highly significant (P=0.001). No difference
was noticed in the PTEN gene expression with regard to different
grades of endometriosis carcinoma (P=0.286). Likewise, no
significant PTENgene expression changes were observed between
the two groups when the age of the patients was introduced for
comparison (P=0.45). Similarly, no significant differences in PTEN
gene expression between the potentially exposed and unexposed
subjects with regard to different stages of the tumor (P=0.98), to
cervix involvement (P=0.532), or to ovarian involvement (P=0.518).
PTEN genetic alteration plays an important role in pathogenesis
of endometrial carcinoma. An obvious and significant increase in
PTEN gene expression profile was spotted between the alleged
exposed and unexposed patients. This observation urges the need
for further molecular study to unfold the extent of DNA damages
caused most probably by the use of DU on the Iraqi population
and the types of damages that DU may cause. The results may
conclude the most disputed arguments about the reasons behind
the high incidence of all types of cancer in the middle and southern
part of Iraq.
Biography
Akeel A, Yasseen, UK0, PhD(UK) and Ph.D. fromQueens University
of Belfast and University of Ulster (United Kingdom) in cytogenetics, molecu-
lar genetics and cancer research. Research fellow at the International Centre
for Genetic Engineering and Biotechnology (United Nation, UNEDO), Trieste,
Italy (1989). Research fellow at the Italian National Research Centre (CNR)
and at the Instituto Superiora Di Sanita in Rome (1990). Visiting Professor at
the University of Ulster School of Biomedical Sciences. (2005). Honorary Ap-
pointing Visiting Professor at the school of Biomedical Science, University of
Ulster (2006 – 2010). Deputy president of the University of Kufa (1991-2001)
and President of the University of Kufa (2011-2017). Patent holder on the Lym-
phocytes stimulation of peripheral blood culture by He-Ne Laser. Currently,
Emeritus professor of Medical and Molecular Genetics at the Department of
Pathology and Forensic Medicine, Faculty of Medicine, University of Kufa, Iraq.
Substantial publication record in peer reviewing journals and skilled in deliver-
ing oral presentations: 50 peer reviewed papers; 53 National and International
Presentations; 2 books Widely ranging research expertise in: molecular genet-
ics, medical genetics and genetic counseling, clinical cytogenetics, cell and
tissue culture, DNA repair.
Fold change in PTENgene expression in endometrial carcinoma
patients who lived in depleted uranium polluted area
Alaa Salah Jummah, Hawraa Sahib Al-Haddad, Emad Hatem and Akeel A Yaseen
Al-Kufi
University of Kufa, Iraq
Alaa Salah Jummah et al., RRJMHS 2018
Volume: 7