ISSN: 1204-5357

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EVALUATION OF LIVER FUNCTIONS WITH MORINGA OLEIFERA LEAF EXTRACT IN CADMIUM INDUCED ADULT WISTAR ALBINO RATS

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Abstract

Cadmium (Cd) is one of the naturally occurring metallic toxicants, affecting various organs. Liver is one of the organs affected by Cd toxicity (acute &chronic exposure).Disruption of the cellular antioxidant system, generation of reactive oxygen species &oxidative stress, etc., are one of the few mechanisms by which cadmium affects the liver. Herbal plants, like, Moringa oleifera, whose health & nutritional benefits like, antioxidant, anti- inflammatory properties, etc., are well documented in a number of scientific literatures, have been used to combat toxicity of these materials. The present study was done to find out the effect of aqueous leaf extract of Moringa oleiferaon liver functions in cadmium exposed adult wistar rats. Male wistar albino rats were divided into four groups & group I was taken as the control. Pre-treatmentwith Moringa leaf extract in cadmium exposed rats showed a significant decrease in the levels of AST (aspartate aminotransferase) & ALT (alanine aminotransferase) as compared to the cadmium alone treated rats. Therefore, the present study suggests that pretreatment with Moringa oleifera leaf extract alters the levels of the liver enzymes & hence canimprove the liver functions in cadmium chlorideinduced rats.However, further studies have to be done to find out the detailed mechanisms of this beneficial effect of Moringa on the liver functions.