Review on Antibiotics
School of Pharmacy, Anurag Group of Institutions, Ghatkesar, Hyderabad, Telangana, India
- *Corresponding Author:
- Vijayalaxmi A
School of Pharmacy, Anurag Group of Institutions, Ghatkesar, Hyderabad, Telangana, India
E-mail: [email protected]
Received Date: 08/06/2016; Accepted Date: 13/06/2016; Published Date: 20/06/2016
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Antibiotics" originates from the Greek hostile to ("against") and bios ("life"). The thing "antibiotics" was proposed in 1942 by Dr. Selman A Waksman, soil microbiologist. An antibiotic is a medication that moderates the development of microorganisms. Antibiotics are one class of antimicrobials, a bigger gathering which additionally incorporates hostile to viral, against contagious, and hostile to parasitic medications. Antibiotics are chemicals delivered by or got from microorganisms (i.e. bugs or germs, for example, microscopic organisms and parasites). The principal anti-microbial was found by Alexander Fleming in 1928 in a huge leap forward for restorative science. Antibiotics agents are among the most every now and again recommended drugs in cutting edge pharmaceutical. Antibiotics are utilized to treat a wide range of bacterial diseases. Antibiotics cure malady by executing or harming microorganisms. Microorganisms are basic one-celled living beings that can be found, by the billions, surrounding us: on furniture and ledges, in the soil, plants and animals. They are a characteristic and required some portion of life. Microscopic organisms cause malady and contamination when they can access more powerless parts of the body and multiply quickly.
Antibiotics, Microorganisms, Drugs, Bacteriostatic, Bactericidal
Antibiotics" originates from the Greek hostile to ("against") and bios ("life"). The thing "antibiotics" was proposed in 1942 by Dr. Selman A Waksman, soil microbiologist.
An antibiotic is a medication that moderates the development of microorganisms. Antibiotics are one class of antimicrobials, a bigger gathering which additionally incorporates hostile to viral, against contagious, and hostile to parasitic medications. Antibiotics are chemicals delivered by or got from microorganisms (i.e. bugs or germs, for example, microscopic organisms and parasites). The principal anti-microbial was found by Alexander Fleming in 1928 in a huge leap forward for restorative science. Antibiotics agents are among the most every now and again recommended drugs in cutting edge pharmaceutical.
Antibiotics are utilized to treat a wide range of bacterial diseases. Antibiotics cure malady by executing or harming microorganisms. Microorganisms are basic one-celled living beings that can be found, by the billions, surrounding us: on furniture and ledges, in the soil, plants and animals. They are a characteristic and required some portion of life. Microscopic organisms cause malady and contamination when they can access morepowerless parts of the body and multiply quickly.
Bacteriostatic antibiotics: Some antibiotics are bacteriostatic, implying that they work by halting microorganisms’ development.
Bactericidal antibiotics: Some antibiotics are bactericidal, implying that they work by eliminating microscopic organisms.
Narrow range antibiotics: Some antibiotics can be utilized to treat an extensive variety of diseases and are known as expansive range antibiotics agents.
Narrow range antibiotics: Some antibiotics are just viable against a couple sorts of microscopic organisms and are called slender range antibiotics agents [1-17].
There are distinctive courses of organization for antibiotics treatment. Antibiotics are typically taken by mouth. In more serious cases, especially profound situated systemic diseases, antibiotics can be given intravenously or by injection [18-20]. Where the site of contamination is effectively gotten to antibiotics agents might be given topically as eye drops onto the conjuctiva for conjunctivitis or ear drops for ear contaminations and intense instances of swimmer's ear. Topical use is additionally one of the treatment choices for some skin conditions including skin break out and cellulitis. Advantages of neighborhood utilization of antibiotics at the site of disease incorporate accomplishing high and managed grouping of antibiotics at the site of contamination, diminishing the potential for systemic ingestion and poisonous quality, absolute volumes of antibiotics required to treat the disease are lessened, and, perhaps, restricting potential for the improvement of anti-microbial resistance [20-24].
Antibiotics are critical in drug, yet lamentably microbes are fit for creating imperviousness to them. Antibiotics safe microscopic organisms are germs that are not murdered by ordinarily utilized antibiotics. At the point when microscopic organisms are presented to the same antibiotics agents again and again, the microbes can change and are no more influenced by the medication [25-36].
Microscopic organisms have number of ways how they get to be antibiotics safe. For instance, they have an inward instrument of changing their structure so the antibiotic no more works, they create approaches to inactivate or kill the antibiotics. Additionally microscopic organisms can exchange the qualities coding for antibiotics resistance between them, making it feasible for microorganisms never presented to an antibiotics to procure resistance from those which have. The issue of antibiotics resistance is declined when antibiotics agents are utilized to treat issue in which they have no viability (e.g. antibiotics are not viable against diseases brought on by infections) and when they are utilized generally as prophylaxis as opposed to treatment [37-43].
Imperviousness to antibiotics represents a genuine and developing issue, since some irresistible illnesses are turning out to be harder to treat. Safe microscopic organisms don't react to the antibiotics agents and keep on causing disease. Some of these safe microscopic organisms can be treated with all the more intense solutions, yet there a few contaminations that are hard to cure even with new or test drugs [44-50].
Most usually utilized sorts of antibiotic agents are: Aminoglycosides, Penicillins, Fluoroquinolones, Cephalosporins, Macrolides, and Tetracyclines. While every class is made out of numerous medications, every medication is remarkable somehow [51-56].
The penicillins are the most seasoned class of antibiotics. Penicillins have a typical compound structure which they impart to the cephalosporins. Penicillins are for the most part bactericidal, hindering arrangement of the bacterial cell divider. Penicillins are utilized to treat skin contaminations, dental diseases, ear contaminations, respiratory tract contaminations, urinary tract contaminations, gonorrhea. Penicillins are among the most secure and slightest poisonous medications. The most widely recognized reaction of penicillin is looseness of the bowels [57-60]. Queasiness, retching, and annoyed stomach are additionally basic. In uncommon cases penicillins can bring about quick or postponed hypersensitive responses which show as skin rashes, fever, angioedema, and anaphylactic stun. Severe hypersensitivity reactions are more common after injections than after oral formulations.
Cephalosporins have a system of activity indistinguishable to that of the penicillins. In any case, the fundamental concoction structure of the penicillins and cephalosporins contrasts in different regards, bringing about various range of antibacterial movement. Like the penicillins, cephalosporins have a beta-lactam ring structure that meddles with combination of the bacterial cell divider as are bactericidal. Cephalosporins are gotten from cephalosporin C which is delivered from Cephalosporium acremonium. Cephalosporins are surprisingly protected class of antibacterials and ordinarily cause couple of unfavorable impacts. Normal symptoms includes the diarrhoea, nausea, mild stomach cramps or upset [61-65]. Around 5–10% of patients with unfavorably susceptible extreme touchiness to penicillins will likewise have cross-reactivity with cephalosporins. In this way, cephalosporin antibactirials are contraindicated in individuals with a background marked by unfavorably susceptible responses (urticaria, hypersensitivity, interstitial nephritis, and so forth) to penicillins or cephalosporins.
Fluoroquinolones (fluoridated quinolones) are the most current class of antibacterial. Their bland name regularly contains the root "floxacin". They are manufactured anti-toxins, and not got from microscopic organisms. Fluoroquinolones have a place with the group of antibiotics agents called quinolones. The more seasoned quinolones are not very much assimilated and are utilized to treat generally urinary tract diseases. Fluoroquinolones are all around endured and moderately sheltered. The most well-known reactions incorporate queasiness, retching, loose bowels, stomach torment. More genuine yet less normal symptoms are focal sensory system anomalies (cerebral pain, perplexity and tipsiness), phototoxicity (more basic with lomefloxacin and sparfloxacin), QT interim prolongation7, tendinopathy and tendon rupture8, and shakings [66-70].
Tetracyclines got their name since they share a substance structure that has four rings. They are gotten from types of Streptomyces microscopic organisms. Tetracycline antibacterial is wide range bacteriostatic operators and work by restraining the bacterial protein combination. Tetracyclines might be viable against a wide assortment of microorganisms, including rickettsia and amebic parasites. Normal symptoms connected with tetracyclines incorporate issues or smoldering of the stomach, looseness of the bowels, queasiness, retching, esophageal ulceration, sore mouth or tongue. Tetracyclines can bring about skin photosensitivity, which expands the danger of sunburn under presentation to UV light [71-76].
The macrolide anti-toxins are gotten from Streptomyces microbes, and got their name since they all have a macrocyclic lactone synthetic structure. Symptoms connected with macrolides incorporate sickness, spewing, and looseness of the bowels; occasionally, there might be transitory sound-related impedance. Azithromycin has been once in a while connected with unfavorably susceptible responses, including angioedema, hypersensitivity, and dermatologic responses [77-80].
Aminoglycoside antibiotics are utilized to treat contaminations brought about by gram-negative microscopic organisms. Aminoglycosides might be utilized alongside penicillins or cephalosporins to give a two dimensional assault on the bacteria.Generally, aminoglycosides are given for brief eras. The major irreversible poisonous quality of aminoglycosides is ototoxicity10 (harm to the ear and hearing). Among them, streptomycin and gentamicin are essentially vestibulotoxic, though amikacin, neomycin, dihydrosterptomycin, and kanamicin are principally cochleotoxic [81,82].
Sulfonamides (sulfa medications) are medications that are gotten from sulfanilamide, a sulfur-containing synthetic. Most sulfonamides are antibiotics agents, however some are recommended for treating ulcerative colitis. Sulfonamide antibiotics agents work by disturbing the creation of dihydrofolic corrosive, a type of folic corrosive that microscopic organisms and human cells use for delivering proteins [83-86].
Glycopeptides of the clinically vital antibiotics medications are glycosylated cyclic or polycyclic nonribosomal peptides. Glycopeptides, for example, vancomycin and teicoplanin are frequently utilized for the treatment of gram-positive microorganisms in patients [87-91]. The expanded rate of medication resistance and insufficiency of this therapeutics against gram-positive bacterial diseases would be the arrangement and clinical advancement of more variable second era of glycopeptide antibiotics agents: semisynthetic lipoglycopeptide analogs, for example, telavancin, dalbavancin, and oritavancin with enhanced movement and better pharmacokinetic properties [92-94].
Oxazolidinones are another gathering of antibiotics agents. These engineered medications are dynamic against an extensive range of Gram-positive microorganisms, including methicillin-and vancomycin-safe staphylococci, vancomycin-safe enterococci, penicillin-safe pneumococci and anaerobes. Oxazolidinones repress protein amalgamation by official at the P site at the ribosomal 50S subunit [94-101].
Most antibacterials were acquired without counseling a specialist. Abnormal amounts of antibiotics resistance and high predominance of multidrug-safe strains were found among respiratory pathogens. The expanded use, and here and there abuse of antibiotic drugs has brought about bacterial imperviousness to a huge and developing number of these medications. In spite of the fact that examination into more up to date antibiotic agents proceeds with, measures can and ought to be taken to turn around the practices that advance improvement of anti-microbial resistance in microscopic organisms.
- Heidari A. Genomics and Proteomics Studies of Zolpidem, Necopidem, Alpidem, Saripidem, Miroprofen, Zolimidine, Olprinone and Abafungin as Anti-Tumor, Peptide Antibiotics, Antiviral and Central Nervous System (CNS) Drugs. J Data Mining Genomics & Proteomics. 2016;7:e125.
- Boamah VE, et al. Antibiotic Practices and Factors Influencing the Use of Antibiotics in Selected Poultry Farms in Ghana. J Antimicro. 2016;2:120.
- Peedikayil FC. Antibiotics in Odontogenic Infections - An Update. J Antimicro. 2016;2:117.
- Gniadkowski M. Evolution of extended-spectrum beta-lactamases by mutation. Clin Microbiol Infect. 2008;14:11.
- Jamil B, Syed MA. Antibiotics: Past, Present and Future. J Biomol Res Ther. 2016;5:e149.
- Zheng Q, Liu W. Thiopeptide Antibiotics act on both Host and Microbe to Deliver Double Punch on Mycobacterial Infection. Mycobact Dis. 2016;6:203.
- Finlay BB and Hancock RE. Can innate immunity be enhanced to treat microbial infections? Nat Rev Microbiol. 2004;2:497.
- Finland M. Emergence of antibiotic resistance in hospitals. Rev Infect Dis. 1979;1:4.
- Napoleone E, et al. Active Surveillance on the Use of Antibiotics in Children, Particularly in the Age Group from 0 to 2 Years. J Pharmacovigil. 2016;4:205.
- Levi-Setti PE, et al. Antibiotics Use in Infertile Couples and During ART Procedures: A Review. JFIV Reprod Med Genet. 2016;4:e120.
- Munasinghe KR, et al. Abdominal Wall and Intra Pelvic Hematoma Presenting as Abdominal Pain after Short Course of Antibiotics in Patients on Long Term Warfarin Therapy.Cardiovasc Pharm Open Access.2016;5:170.
- Oyle MP. Antimicrobial resistance: implications for the food system. Compr. Rev. Food Sci. Food Saf. 2006;5:71.
- Verbeken G, et al. Viruses That Can Cure, When Antibiotics Fail…. J Microb Biochem Technol. 2015;8:465.
- Jing Sun and Peter Hawkey. A Review of the Use of and Resistance to Antibiotics in China A Way Forward to Reduce Resistance. J Hos and Clini Pharma. 2016;
- Saleem F and Hassali MA. Promoting Quality Use of Antibiotics in Dveleoping Countires: New Societal Approach. Health Econ Outcome Res Open Access. 2016;2:e103.
- Datta N and Hughes VM. Plasmids of the same Inc groups in enterobacteria before and after the medical use of antibiotics. Nature.1983;306:616.
- Chandra A (2016) The Incidence and Outcome of Hemodialysis Catheter-Related Blood Stream Infection and the Sensitivity Pattern of the Isolated Organisms to the Antibiotics in ESRD Patients. J Nephrol Ther 6:244.
- Bryskier A. Antimicrobial agents: antibacterials and antifungals. ASM Press, Washington, DC.
- Zaky MM. Environmental factors influencing multi-drug resistant and harboring plasmid DNA Aeromonas hydrophila isolated from polluted water of Lake Manzala, Egypt. Proceedings of the 19th Iaps International Conference on Environment, Health and Sustainable Development, Sept. 11-16, Alexandria, Egypt. 2006;159.
- Brötze-Oesterhelt H and NA Brunner. How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008;8:564.
- Abbassy MS, et al. Persistent organochlorine pollutants in the aquatic ecosystem of Lake Manzala, Egypt.Bull Environ ContamToxicol. 2003;70:1158.
- El-Sarangawy DA. Pathogenic indicators of water in six wastewater resources in Lake Manzala, North Egypt. Part I, Bahr El-Bakar. Zagazig Vet J. 2016;18:26.
- El-Gaber GA, et al. Vibrio species infections in Orechromisniloticus and Mugilcephalus, sodium chloride tolerencepathogenecity, serological relatedness and antibiograms sensitivity of recovered vibrios. Vet Med J. 1997;45:87.
- Balaban NT, et al. Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science. 1988;280:438.
- Sulayman ZI. Antibiogram of some bacteria contaminating Tilapia fish at El-Manzala Lake in Port-Said Governorate. Vet Med J. 1991;27:19.
- Andersson DI. The biological cost of mutational antibiotic resistance: any practical conclusions? Curr Opin Microbiol. 2006;9:461.
- Zaky MM, et al. Environmental and health significance of toxigenic Aeromonas sobria and Aeromonas hydrophila in polluted water of Lake Manzala, Egypt. Proceedings of the 26th African Health Congress. 2005.
- Fowler J and Cohen L. Practical statistics for field Biology. John Willy and Sons, England. 1996.
- Aminov, et al. Evolution and ecology of antibiotic resistance genes. FEMS Microbiol Lett 2002;271:147.
- Maniatis T, et al. Molecular Cloning a Laboratory Manual. Cold Spring Harbor Laboratory, New York, USA. 1982;149.
- Shaheen AH and Youssef SF. The effect of the cessation of Nile flood on the hydrographic features of lake Manzala, Egypt. Arch Hydrobiol. 1978;48:339.
- Khalil MT. The physical and chemical environment of Lake Manzala, Egypt. Hydrobiologia; 1990;196:193.
- Hamed YA, et al. Assessment of heavy metals pollution and microbial contamination in water, Sedemints and fish of Lake Manzala, Egypt. Life science journal. 1998;10:86.
- Aminov RI. The role of antibiotics and antibiotic resistance in nature. Environ. Microbiol. 2009;11:2970.
- Abdelhamid AM, et al. Bacteriological status of ashtom El-Gamil protected area. J Aquat Biol & Fish. 2013;17:11.
- Levin MA, et al. Microbial Ecology (1stedn.) McGraw-Hill, New York. 1992;11-25.
- Paape MJ, et al. Pharmacologic enhancement or suppression of phagocytosis by bovine neutrophils. Am J Vet Res 1991;52:363.
- Urbina D, et al. Rotavirus type A and other enteric pathogens in stool samples from children with acute diarrhea on the Colombian northern coast. Int Microbiol. 2003;6:27.
- Saleh AR, et al. Microbiological water quality and bacterial infections among Tilapia fish of Lake Manzala, Egypt. International journal of environment & water. 2013;2:75.
- Chang FT, et al. In vitro effect of actinomycin D on human neutrophil function. Microbiol Immunol 1990;34:311.
- Dumontet S, et al. Incidence and characterisation of Aeromonas spp. in environmental and human samples in southern Italy. New Microbiol. 2003;26:215.
- Pianietti A, et al. Faecal contamination indicators, Salmonella, Vibrio and Aeromonas in water used for the irrigation of agricultural products. Epidemiol. Infect. 2004;132:231.
- Paape MJ, et al. In vivo effects of chloramphenicol, tetracycline, and gentamicin on bovine neutrophil function and morphologic features. Am J Vet Res.1991;51:1055.
- Critchley MM, et al. The influence of the chemical composition of drinking water on cuprosolvency by biofilm bacteria. J Appl Microbiol. 2003;94:501.
- Hoefel D, et al. Profiling bacterial survival through a water treatment process and subsequent distribution system. J Applied Microbiol. 2005;99:175.
- Berg G, et al. Genotypic and phenotypic relationships between clinical and environmental isolates of Stenotrophomonas maltophilia. J Clin Microbiol. 2009;37:3594.
- Boktour M, et al. Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patients.Cancer. 2006;106:1967.
- Sheng FC, et al. The effects ofin vivo antibiotics on neutrophil (PMN) activity in rabbits with peritonitis. J Surg Res 2009;43:239.
- Labro MT and el-Benna J. Effects of anti-infectious agents on polymorphonuclear neutrophils. Eur. J. Clin. Microbiol. Infect Dis 1991;10:124.
- del Toro MD, et al. Epidemiology, clinical features and prognosis of infections due to Stenotrophomonas maltophilia. EnfermInfecc Microbiol Clin. 2006;24:4.
- Bennett JV and Brachman PS. Hospital Infections. (3rdedn), Little, Brown & Company, Boston, Toronto, London. 1992.
- Duguid JP. Staphylococcus: Cluster forming Gram positive cocci. In: Mackie & Mc Cartney Practical Medical Microbiology. (13thedn), Collee JG, Duguid JP, Fraser AG, Marmion BP (Editors.) Churchill Livingstone, Edinburgh London Melborne, New York. 1989;303.
- Collee JG, et al. Mackie and Mc Cartney Practical Medical Microbiology. (13thedn) Churchill Livingstone, Edinburgh London Melborne, New York. 1989.
- Bauer AW, et al. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966;45:493.
- Garner JS. Guideline for Prevention of Surgical Wound Infections. R. N. M. N. Hospital Infection Program Centres for Infectious Diseases Centre for Disease Control. 1985.
- Prabhakar H and Arora S. A bacteriological study of wound infections. J Indian Med Assoc. 1978;73:145.
- Agrawal PK, et al. Incidence of Post- operative wound infection at Aligarh. Indian J Surg. 1984;46:326.
- Kowli SS, et al. Hospital Infection. Ind J Surg. 1985;47:475.
- Corrales I, et al. Immunomodulatory effect of cefminox. J Antimicrob Chemother. 1994;33:372.
- Anvikar AR, et al. A one year prospective study of 3280 surgical wounds. Ind J Med Microbiol. 1990;17:129.
- Murthy R, et al. Incidence of post-operative wound infection and their antibiogram in a teaching and referral hospital. Indian J Med Sci. 2009;52:553.
- Tripathy S, Roy (1984) Post-operative wound sepsis. Indian J Surg 46: 285-288.
- Carevic O and Djokic S. Comparative studies on the effects of erythromycin A and azithromycin upon extracellular release of lysosomal enzymes in inflammatory processes. Agents Actions. 1988;25:124.
- Sheridan RL, et al. Prophylactic antibiotics and their role in the prevention of surgical wound infection. Adv Surg. 1994;27:43.
- Yalçin AN, et al. Postoperative wound infections. J Hosp Infect. 1995;29:305.
- Khan MA, et al. Post-operative wound infection. Indian J Surg. 1985;47:383.
- Smith RL, et al. Wound infection after elective colorectal resection. Ann Surg. 2005;239:599.
- Ringoir S. The “infection equation.” Infection. 1992;20:S75-S77.
- Pradhan GB and Agrawal J. Comparative study of post-operative wound infection following emergency lower segment caesarean section with and without the topical use of fusidic acid. Nepal Med Coll J. 2009;11:189.
- Colling KP, et al. Abdominal Hysterectomy: Reduced Risk of Surgical Site Infection Associated with Robotic and Laparoscopic Technique. Surg Infect. 2015;16:498.
- Catanzarite T, et al. Longer Operative Time During Benign Laparoscopic and Robotic Hysterectomy Is Associated With Increased 30-Day Perioperative Complications. J Minim Invasive Gynecol. 2015;22:1049.
- Milatovic D. Antibiotics and phagocytosis. Eur J Clin Microbiol. 1983;2:414.
- Anand M, et al. Perioperative complications of robotic sacrocolpopexy for post-hysterectomy vaginal vault prolapse. Int Urogynecol J. 2005;25:1193.
- Prokopovich P, et al. A novel bone cement impregnated with silver-tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties. Int J Nanomedicine. 2015;8:2227.
- Martov A, et al. Clinical Research Office of the Endourological Society Ureteroscopy Study Group. Postoperative infection rates in patients with a negative baseline urine culture undergoing ureteroscopic stone removal: a matched case-control analysis on antibiotic prophylaxis from the CROES URS global study. J Endourol. 2015;29:171.
- Gemmell CG. Antibiotics and neutrophil function — potential immunomodulating activities. J Antimicrob Chemother. 1993;31:23.
- George AK, et al. Surgical site infection rates following laparoscopic urological procedures. J Urol. 2007;185:1289.
- Holly FJ. Formation and stability of the tear film. Int Ophthalmol Clin. 2007;13:73.
- van den Broek J. Antimicrobial drugs, microorganisms, and phagocytes. Rev Infect Dis. 1989;11:213.
- Morrow GL, et al. Conjunctivitis. Am Fam Physician. 1998;57:735.
- Wood M. Conjunctivitis: diagnosis and management. Community Eye Health. 1999;12:19.
- Senaratne T and Gilbert C. Conjunctivitis. Community Eye Health. 1998;18:73.
- Levy SB. Antibiotic resistance: consequences of inaction. Clinical Infectious Diseases 2001;3: S124.
- Hovding G. Acute bacterial conjunctivitis. Tidsskr Nor Laegeforen. 2001;124:1518.
- Korzeniowski OM. Effects of antibiotics on the mammalian immune system. Infect Dis Clin North Am 1998;3:469.
- Witte W. Medical consequences of antibiotic use in agriculture. Science. 1998;279:996.
- Sheik A, et al. Antibiotics for acute bacterial conjunctivitis. Cohrane Database Syst Rev. 2001;CD001211.
- David SP. Should we prescribe antibiotics for acute conjunctivitis. Am Fam Physician 2002;66:1649.
- Sheikh A and Hurwitz B. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2011;19:CD.
- Seewoodhary R and Stevens S Transmission and control of infection in ophthalmic practice. Community Eye Health. 1998;12:25.
- Sheldrick JH, et al. Management of ophthalmic disease in general practice. Br J Gen Pract. 1998;43:459.
- Hauser WE and Remington JS. Effect of antibiotics on the immune response. Am J Med. 1982;72:711.
- Hørven I. Acute conjunctivitis. A comparison of fusidic acid viscous eye drops and chloramphenicol. Acta Ophthalmol (Copenh). 1993;71:165.
- McCormic KA, et al. Morbidity statistics from general practice: Fourth National Study 1991-1992. London: HMSO. 1995.
- Bodor FF. Diagnosis and management of acute conjunctivitis. Semi Infect Dis. 1988;9:27.
- Levy SB. Playing antibiotic pool: time to tally the score. New England Journal of Medicine. 1984;311:663.
- Phillips I. Antibiotic policies. In Recent Advances in Infection 1. 151-63. Churchill Livingstone, Edinburgh, UK.
- Gordon WS. The control of certain diseases of sheep. Veterinary Record. 1934;14:1-8.
- Schwabe CW. Animal protein and human hunger. In Veterinary Medicine and Human Health. 2008;123:41.
- Jacoby GA. AmpC β-lactamases. Clin Microbiol Rev. 2009;22:161.
- Hakenbeck R. Mosaic genes and their role in penicillin-resistant Streptococcus pneumoniae. Electrophoresis. 1988;19:597.