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Development of reliable and eco-friendly process for synthesis of nanoparticles is an important step in the field the of nanotechnology. Nanotechnology involves the tailoring of materials at the atomic level to attain unique properties, which can be suitably manipulated for the desired applications. Among them silver nanoparticles draw attention due to its unique physical, chemical and biological properties. Green principle route of synthesizing have emerged as alternative to overcome the limitation of conventional methods among which plant and microorganisms are majorly exploited. Employing plants towards synthesis of nanoparticles are emerging as advantageous compared to microbes with the presence of broad variability of bio molecules in plants can act as capping and reducing agents and thus increases the rate of reduction and stabilization of nanoparticles. This review focuses on the green synthesis of silver nanoparticles using various plant sources and its applications in cancer treatment. Generally surgery, chemotherapy and radiation treatment are the most prevalent therapeutic option for cancer . Unfortunately these treatments have various side effects due to lack of targeted delivery and cancer specificity. To overcome these limitations, nanoparticle could ensure targeted drug therapy having very little side effects. In this review focus is given to silver nanoparticle, synthesized from natural plant extracts, as it is cost effective, eco-friendly, stable and safe in cancer treatment.