Models to Evaluate Anti-Anxiety Effect
Nowadays various models are available to evaluate anxiolytics effect of a new entity or even for comparative studies with the standard drug. Animal models are very useful to understand the pathogenesis of the disease and also helpful in finding the treatment of the particular disease. As per the ethics, a new compound or drug believes to have possible pharmacological effect should be tested on animals before tested on humans which have similar physiology than humans. Anxiolytics are the agent which are used to elevate anxiety effect produced due to any cause. Whenever a new drug believes to have a possible pharmacological response, an animal model is developed to verify the effect of the drug which study is also known as a preclinical study. First, rats were used as an animal model for evaluation of anti-anxiety drug but later on the various strain of mice were added to an animal model for evaluation of anxiolytics because of better genetic possibilities than rats. In this review article, we have discussed the most commonly used four animal models used to evaluate the anti-anxiety effect. The various parameter will be undertaken for the better and precise evaluation of anxiolytics. Behavioral studies can also be conducted with the help of some animal models used to evaluate the anti-anxiety effect.
Himanshu*, Nutan and Deepa