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Semicarbazide and Thiosemicarbazide are classes of Schiff bases prepared by condensation between aldehydes / ketones with amines, they are belongs to urea and thiourea derivatives whose pharmacological activities are a function of attached aldehydes or ketones moiety. Semicarbazide and thiosemicarbazide have potential pharmacological activities including antifungal, anticancer, antibacterial, antimalarial, anticonvulsant, antitubercular, anti-proliferative, anti-inflammatory, antimicrobial, analgesic, antioxidant, radical scavenging, antiviral, and antipyretic properties. Thiosemicarbazides derivatives are of great interest not only in pharmacological activities, but also as the starting material for the preparation of different Schiff base derivatives, metal chelating complexes and anticorrosion agents. This review aim to evaluate the different biological activities of synthesized semicarbazide and thiosemicarbazide derivatives.