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National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Key Laboratory of Zoonoses, Ministry of Agriculture, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Animal Infectious Diseases Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
Received date: 28/02/2020; Accepted date: 10/03/2020 Published date: 17/03/2020
Visit for more related articles at Research & Reviews: Journal of Microbiology and Biotechnology
In China, non-typhoid Salmonella is an important foodborne pathogen and results in 70% -80% of bacterial food poisoning every year . The majority of salmonellosis is caused by Salmonella enterica serovar Enteritidis and Salmonella enterica serovar Typhimurium . Salmonella enterica serovar Kentucky (S. Kentucky) is an important serotype that has severely endangered human health in the United States and Europe in recent years, showing a high resistance to ciprofloxacin and a rapid cross epidemic of human and animal strains [3-5]. Zhiying Xiong and colleagues published the article entitled: “Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 in Broiler Chicken Supply Chain and Patients, China, 2010–2016” in the journal Microorganisms , which is the first time to systematically reveal that S. Kentucky is a significant serotype widely distributed in humans, poultry, food and environment in China. The prevalent ST type of S. Kentucky is complex and S. Kentucky ST198 and S. Kentucky ST314 (unpublished data) are the dominated ST type. Drug-resistant S. Kentucky ST198 is severe, of which the 63 S. Kentucky ST198 isolates, up to 90% of the strains showed multiple drug resistance (MDR, resistance to at least three antibiotics), while more than 60% of the strains simultaneously showed high resistance to ciprofloxacin (MIC ≥ 16) and MDR. Furthermore, 14.3% of ST198 strains displayed co-resistance to cefotaxime (MIC ≥ 32), ciprofloxacin and MDR. More importantly, the study found that S. Kentucky ST198 poses a risk of cross-source transmission between humans, poultry and food, especially the resistant strains. What worries us is that ciprofloxacin and cefotaxime are effective options for the treatment of clinical non-typhoid Salmonella infections, especially multidrug-resistant non-typhoid Salmonella infections . However, high resistance rates to ciprofloxacin and/or cefotaxime have been observed in multidrug-resistant S. Kentucky ST198, which greatly increases the difficulty of clinical treatment and poses a serious threat to public health.
It is worth noting that we isolated a strain of S. Kentucky in the blood sample of a clinical 13 year old girl in 2014 in Xinjiang, China (The data did not publish before). The antimicrobial susceptibility testing of the strain showed that the strain was resistance to tetracycline, nalidixic acid, streptomycin, chloramphenicol and sulfisoxazole, while displayed susceptibility to cefotaxime, cefepime, polymyxin, ampicillin, ofloxacin and ciprofloxacin. Our study has confirmed that S. Kentucky has the ability to cause blood infections and the strain exhibited MDR. As the invasive nontyphoidal Salmonella (iNTS) infections are much more severe than self-limiting diarrhea caused by nontyphoidal Salmonella infections . INTS usually causes sepsis and meningitis in low-income areas and the multiple-drug resistant iNTS isolates are more likely to cause death during treatment . Fortunately, the strain of S. Kentucky is susceptible to first-line drugs, such as ciprofloxacin and cefotaxime, but treating Salmonella infections in the blood are still very difficult and complexity, especially the multidrug-resistant strains. Therefore, this is a serious threat to human health that deserves our concern.
Understanding the origin and spread of bacterial resistance is important for predicting the occurrence and transmission of clinically relevant bacteria . Many researchers have hypothesized that drug-resistant bacteria can be spread to humans from farms . However, people have debated whether the drug-resistant strains produced by animals are the sources that cause human infections for many years [10,11]. In the study of Zhiying Xiong and colleagues , 20.6% of the S. Kentucky ST198 strains (including the human and non-human strains) were resistance to florfenicol. Florfenicol is a kind of antibiotic specially used in livestock and poultry breeding in China , which supports that the bacterial resistance produced in farms can be transmitted to humans. Moreover, China is the world's largest producer and consumer of antibiotics, producing more than 200,000 tons of antibiotics each year and about 50% of which are used in farms , which causes farms as a significant origin of drug-resistant pathogens. Furthermore, most antibiotics like cephalosporins and quinolones are used in both human and farms, which means that animal-derived resistant strains are also resistance to human antibiotics, making clinical antibiotics more difficult to effectively treat bacterial infections . It reminds us of the need for comprehensive monitoring of antibiotic use and resistance in farms.
Zhiying Xiong and colleagues study  is a very meaningful study to provide reliable data support and effective reference opinions for the prevention and monitoring of the disease through the molecular epidemiological study of S. Kentucky ST198 in China. The insufficience is that study does not use the whole genome instead of PFGE to trace the source of S. Kentucky ST198, which is more comprehensive and accurate.
This work was supported by the National Key R&D Program of China (2018YFD0500500, 2017YFC1600101); National Natural Science Foundation of China (31972762); Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2018); Pearl River S&T Nova Program of Guangzhou (201806010183); Province Science and Technology of Guangdong Research Project (2017A020208055); Guangdong Key S&T Program (Grant no. 2019B020217002) from Department of Science and Technology of Guangdong Province; Walmart Foundation (SA1703162); National Broiler Industry Technology System Project (cARS-41-G16).
The authors have no financial conflicts of interest to declare.