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Research Article Open Access

Coexistence of Familial Amyotrophic Lateral Sclerosis and Sporadic Inclusion Body Myositis – A Case Report

Abstract

Many inclusion body myositis (IBM) patients have been misdiagnosed as amyotrophic lateral sclerosis (ALS). We report a case of IBM coexisting with familial ALS.

Clinically, Inclusion body myositis (IBM) patients have been misdiagnosed as amyotrophic lateral sclerosis (ALS). Recent studies have shown that mutations of valosin-containing protein (VCP) are involved in ALS and IBM. ALS and IBM may share similar pathogenesis of multisystem proteinopathy. We report a case of sporadic IBM coexisting with familial ALS (fALS).

Udaya Bhat, Bo Wang, Padma Kumar and Yi He

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