Mucoadhesive Patch: A Novel Drug Delivery.
During the past few decades, advances in drug formulations and innovative routes of administration have been made and simultaneously our understanding of drug transport across tissues has increased. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed, to safely achieve its desired therapeutic effects. It is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. It is a concept heavily integrated with dosage form and route of administration. Also these technologies and mode of administration modify the drug release profile, and other pharmacokinetics and dynamics. Oral mucous membrane being vascular, highly permeable and accessible, allows for the systemic uptake of drugs painlessly and at a steady rate of delivery also bypassing the stomach environment and first-pass liver metabolism. The use of mucoadhesive polymers in buccal drug delivery has a greater application. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. However, buccal patch offer greater flexibility and comfort than the other devices. This review enlightens about these novel drug delivery by mucoadhesive patches, their history, manufacturing, properties, advantages and disadvantages.
Rajeshwari G Annigeri, and Manisha Jadhav