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Research Article Open Access

Screening of Anti-Convulsant Activity of Methonalic Extract of Aerial Parts of Canna indica

Abstract

Aim: The aim of the present study is to explore the “Screening of anticonvulsant activity of methanolic extract of aerial parts of Canna indica” in albino mice. Materials and method: Collection and authentication of aerial parts of Canna indica L. Preparation of methanolic extract of aerial parts of Canna indica L. Assesment of toxicity studies of Canna indica L. Screening of anticonvulsant activity by: • Maximal electroshock method • Isoniazid induced seizures • Strychnine induced seizures Results: Methanolic extract of aerial parts of Canna indica L. decreased the duration of tonic hind leg extension in maximal electroshock-induced seizures probably by acting on voltage gated sodium ion channels. The latency of convulsion and decreased the seizure threshold by acting on the GABAergic system, glutaminergic mechanism and Na+, Ca+ channels. Methanolic extract of aerial parts of Canna indica L. did not Showed any protection against strychnine induced convulsions even at highest dose, 400 mg/kg probably acting on glycinergic transmission. Methanolic extract of aerial parts of Canna indica. L did not Showed any protection against Isoniazid induced convulsions even at highest dose, 400 mg/kg probably acting on glycinergic transmission. Discussion: In the present study we have evaluated the effect of methanolic extract of aerial parts of Canna indica L. against seizures induced by maximal electroshock (MES), isoniazid (INH) and strychnine in mice. Conclusion: The findings of the present study lend pharmacological credence to the suggested folkloric, ethno medical uses of Canna indica L. as a natural supplementary remedy for the reveals that plants of Canna indica shows MES induced seizures which could be by interfering with GABA, glutaminergic mechanism and Na+, Ca+ channels. However, the exact mechanism and the active principle by which these extracts exert their action remain unclear. Further studies are required to study the individual mechanism of actions.

Yousuf Uddin and DV Kishore

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