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Volume 6 Research & Reviews: Journal of Material Sciences
ISSN: 2321-6212 Advanced Materials 2018
September 04-06, 2018
September 04-06, 2018 | Zürich, Switzerland
21st International Conference on
Advanced Materials & Nanotechnology
Advances in 3D printing in biomaterials for orthopaedic applications
Dan Li1, 2, Pravin Vence1, Yaoyi Huang2, Hong Shen2, Yunlong Ma2 and Yuanzheng Ma2
1Northwestern University, USA
2309 th Hospital of the PLA, China
3D printing aims to deliver intricate biomedical devices based upon advanced diagnostic imaging. With the current upsurge in public
interest and increasing access to low-cost printers, efforts are underway to produce patient-specific anatomical models, customized
implants, and individualized instrumentation. Examples include the development of disposable surgical saw guides and cutting blocks
in total knee arthroplasty. These devices help minimize tissue loss and optimize the native biomechanics of the patient. This review
explores the evolution of 3D printing technology in the context of biomaterials. It also aims to critiques the major challenges ahead
in optimizing bioinks and biologic performance in bringing 3D bioprinting to clinical practice. Common materials include metals,
bioceramics, synthetics, and natural polymers; each having specific mechanical properties, processing methodology and cell-material
interaction. Biofunctional biomaterials are an emerging class of materials that display adaptability and activity at every phase of bone
growth.These biomaterials have been shown to promote osteogenic differentiation, improve calciumphosphate (CaP) precipitation, and
regulate osteoblast gene expression. When crafted to emulate the specific micro-environment of bone, polymer-surface modifications
accelerate bony ingrowth. 3D printing holds promise as a scaffold for bone regeneration as precise control of the overall geometry
and internal porous structure. The accompanying biomaterials may be successfully embedded within multi-cellular co-cultures and
specific growth factors modulated to optimize growth and fixation. Bioceramics such as hydroxyapatite (HA), calcium phosphate,
and bioglass, are osteogenic and promote cell proliferation, though they have been shown to lack appropriate mechanical strength.
Composite scaffolds of HA and tricalcium phosphate and polycaprolactone (PCL)-HA with carbon backbones have been investigated
to optimize biocompatibility and architecture to improve the porosity and mechanical strength of these constructs. Furthermore,
microscale manipulation of biomaterials allow for integration of antimicrobial properties to combat infection.
Recent Publications
1. Butler B A, Fitz D W, Lawton C D, Li D, Balderama E S and Stover M D (2018) Early diagnosis of septic arthritis in
immunecompromised patients. Journal of Orthopaedic Science 23(3):542-545.
2. Li D, Pengfei L, Linfeng F, Huang Y, Yang F, Mei X and Wu D (2017) The immobilization of antibiotic-loaded polymeric
coatings on osteoarticular ti implants for the prevention of bone infections. Biomaterials Science 5(11):2337–2346.
Dan Li et al., Res. Rev. J Mat. Sci. 2018, Volume 6
DOI: 10.4172/2321-6212-C3-021