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Volume 6
Research & Reviews: Journal of Material Sciences
ISSN: 2321-6212
Advanced Materials 2018
September 04-06, 2018
September 04-06, 2018 | Zürich, Switzerland
21
st
International Conference on
Advanced Materials & Nanotechnology
Designing and application of biomaterials based cross-linked hybrid hydrogels
Anujit Ghosal, Shivani Tiwari
and
Jaydeep Bhattacharya
Jawaharlal Nehru University, India
Statement of Problem:
Polymeric hydrogels are three dimensional (3D) interpenetrating (IPN) polymeric materials with
high affinity and ability to hold water or molecular species within. Hybrid hydrogels can be considered as an advance material
due to synergistic cocktail of organic and inorganic components. However, only an optimum concentration of the individual
components can result in a stable, bio-compatible and cell sustaining hybrid hydrogel. Chitosan is a well-known biopolymer
however, stiffness in the free standing dry films or high toughness in 3D structures results in brittle nature of the matrix. So,
here we report the effect of secondary bio-polymers (Guar gum, PVA and glycerol) and inorganic nano-filler (Graphite) on the
physico mechanical, physicochemical and bio-compatibility properties of the hybrid hydrogels.
Methodology &Theoretical Orientation:
Longer chain length has the ability to increase the flexibility of the resulting hydrogel
matrix in one hand, whereas, it also decreases the stability of 3D structure. So, along with co-polymeric mixture addition of
graphite would certainly enhance the stability and intactness of the 3D structure. Additionally, dispersion of graphite also
improves the cell adhesion and cell proliferation in the 3Dhybrid hydrogel matrix. A set of hydrogels were designed with varying
concentration of components over fixed and optimum concentration of graphite nanostructure. Optimum concentration of
graphite was defined by the parameters such as cell adhesion, viability, proliferation of human embryonic kidney (HEK-293)
cell line and A549, adeno carcinomic human alveolar basal epithelial cells, along with the swelling ability of the resulting
hydrogels.
Findings:
The ten times improvement in physico mechanical, chemical and swelling properties with higher cell adhesion
efficiency of the hybrid materials projects their potential in the fields of advance materials for 3D cell culturing and tissue
engineering.
anujitghosal@gmail.comRes. Rev. J Mat. Sci. 2018, Volume 6
DOI: 10.4172/2321-6212-C3-021