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Volume 6
Research & Reviews: Journal of Material Sciences
ISSN: 2321-6212
Advanced Materials 2018
September 04-06, 2018
September 04-06, 2018 | Zürich, Switzerland
21
st
International Conference on
Advanced Materials & Nanotechnology
Confined nanoscale geometries to enhance sensitivity of plasmonic immunoassays
Rishabh Rastogi
1
, Suresh Poovanthingal
2
, Pierre Michel Adam
3
, Jewgeni Starikov
4
, Saulius Juodkazis
5
and
Sivashankar Krishnamoorthy
1
1
Luxembourg Institute of Science and Technology, Luxembourg
2
University of Luxembourg, Luxembourg
3
Université de Technologie de Troyes, France
4
Karlsruhe Institute of Technology, Germany
5
Swinburne University of Technology, Australia
S
ensitive transduction of bio-molecular binding events on chip carries profound implications to the outcome of a range
of biological sensors. This includes biosensors that address both research as well as diagnostic questions of clinical
relevance, e.g., profiling of biomarkers, protein expression analysis, drug or toxicity screening and drug-efficacy monitoring.
Nanostructured biosensors constitute a promising advance in this direction owing to their ability in catering to better
sensitivity, response times and miniaturization. Plasmonic sensors are particularly interesting among nano-biosensors as they
exploit light matter interactions in the nanoscale to transduce bio-recognition events with high sensitivity and miniaturized
measurement footprints. Examples of plasmonic sensors include localized surface plasmon resonance spectroscopy (LSPR),
surface enhanced Raman spectroscopy (SERS) and metal-enhanced fluorescence (MEF). The performance of the plasmonic
sensors critically relies on ability to engineer nanoscale geometric attributes at length scales that typically overlap with the
size of small proteins. Such geometries invariably introduce constraints on the molecular binding response, thus altering the
interaction outcomes, viz. density and kinetics of adsorption, molecular orientations, in a manner that would impact the
resulting optical response. A careful engineering of the nanoscale geometries can simultaneously take advantage of EM field
enhancements together with molecular interaction within nanoscale geometries. To this end, this project aims at an engineered
nanoscale interface with geometry tailored to simultaneously favor molecular adsorption and plasmonic enhancements for
application to plasmonic sensors based on surface-enhanced Raman and fluorescence spectroscopies.
rishabh.rastogi@list.luRes. Rev. J Mat. Sci. 2018, Volume 6
DOI: 10.4172/2321-6212-C3-021