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Alzheimer Disease


Alzheimer disease is a neurodegenerative disorder that is characterized by a slow and progressive loss of cognitive functions. In developed countries it is most common form of late-onset dementia over 60 years old. The main pathological hallmarks of AD are extracellular amyloid plaques, intracellular neurofibrillary tangles, and loss of neurons and synapses. These changes result in a cerebral atrophy with cognitive and neuropsychiatric symptoms. The vast majority of cases of Alzheimer's disease are late-onset cases over 60 years. However, there are early forms of AD in which genetic load is high and associated with mutations in APP, PSEN1, and PSEN2 genes. OMICS International Group thru its Open-access Initiative is dedicated to make authentic and dependable contributions to scientific community.

Relevant Topics in Medical Sciences