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Bacterial Polysaccharides



Bacterial polysaccharides represent a various range of macromolecules that include peptidoglycan, lipopolysaccharides, capsules and exopolysaccharides; compounds whose functions range from structural cell-wall components (eg peptidoglycan), and important virulence factors (eg Poly-N-acetylglucosamine in S. aureus), to permitting the bacterium to survive in harsh environments (eg Pseudomonas aeruginosa within the human lung). Polysaccharide biosynthesis may be a tightly regulated, energy intensive process and understanding the subtle interplay between the regulation and energy conservation, polymer modification and synthesis, and therefore the external ecological functions may be a huge area of research. The potential benefits are enormous and will enable for instance the event of novel antibacterial strategies (eg new antibiotics and vaccines) and therefore the commercial exploitation to develop novel applications.




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