Research and Reviews - International Journals

Research & Reviews: Journal of Medical and Health Sciences

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ISSN: 2319-9865

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CNS Inflammation

There is an increasing recognition that inflammation plays a critical role in neurodegenerative diseases of the CNS, including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and therefore the prototypic neuroinflammatory disease MS (MS). Differential immune responses involving the adaptive versus the innate system are observed at various stages of neurodegenerative diseases, and should not only drive disease processes but could function therapeutic targets. Ongoing investigations into the precise inflammatory mechanisms that play roles in disease causation and progression have revealed lessons about inflammation-driven neurodegeneration which will be applied to other neurodegenerative diseases. An increasing number of immunotherapeutic strategies that are successful in MS are now being applied to other neurodegenerative diseases. Some approaches suppress CNS immune mechanisms, while others harness the system to clear deleterious products and cells

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