Electrophoresis is an important technology for the separation and analysis of nucleic acids. natural action of nucleic acids is employed habitually at the workbench for the isolation and manipulation of cloned DNA fragments. additionally, it's a vital part of the many biology protocols that assess the role and interaction of nucleic acids in cells and tissues. macromolecule natural action has earned specific importance within the current era of ordering sequencing. during this application, speed and accuracy of macromolecule analysis square measure of important scientific and economic interest, and also the follow of macromolecule natural action has evolved to mirror these desires. during this article, the chemistry aspects of macromolecule natural action square measure printed and also the major techniques used for the natural action of nucleic acids square measure delineated .