Miraculous effects medicinal plants manifest in curing a vast range of diseases and disorders affecting humans so, we can be better called as ???elixirs of life.??? During the last decay, there is much-growing interest in the use of these medicinal plants as modulators of the complex immune system. To explore of the immunomodulatory properties of many of the chemicals in the medicinal plants in the form of alkaloids, flavonoids, terpenoids, polysaccharides, lactones, and glycoside products which are responsible to cause alterations in the immune response. The aim of this review with a purpose to globally popularize the medicinal plants has a role of immunomodulation.