Department of Pharmaceutical Science, Minia University, Minia, Egypt
Received: 03-Apr-2023, Manuscript No. JPPS-23-93984; Editor assigned: 05-Apr-2023, Pre QC No. JPPS-23-93984 (PQ); Reviewed: 19-Apr-2023, QC No. JPPS-23-93984; Revised: 05-Jul-2023, Manuscript No. JPPS-23-93984 (R); Published: 12-Jul-2023, DOI: 10.4172/2320-1215.12.4.001
Citation: Ramsey D. Interdisciplinary Relationship between Medicinal Chemistry and Pharmacological/Pharmaceutical Concepts Involved. RRJ Pharm Pharm Sci. 2023;12:001.
Copyright: © 2023 Ramsey D. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Medicinal chemistry concerns the discovery, the development, the identification and the interpretation of the mode of action of physiologically active substances at the molecular level. Drugs are the focus, although medicinal chemist’s interests extend beyond just pharmaceuticals to bioactive molecules in general. The research, identification, and synthesis of these medications metabolic by products as well as those of related molecules are all aspects of medicinal chemistry”.
The study, comprehension, designs, and experimental manipulation of molecular structure that alters biological function in a physiological and/or pathological system is known as medicinal chemistry. It involves sophisticated puzzle solving abilities and is both a science and an art. The study of how chemical structure determines physicochemical qualities, how these properties cause physiological function, and how these properties regulate the fate of the molecule in complete organisms is based on medicinal chemistry. The creation and sourcing of compounds, structural analysis, and mode of action investigations of prospective novel medications are among the medicinal chemist's primary competencies.
Chemicals, both natural and synthetic, are utilised in drugs for medical purposes. They engage with the intricate chemical systems in people's or animals' bodies. This interaction is the subject of medicinal chemistry, which focuses on the organic and biochemical interactions between pharmacological molecules and their targets. One element of drug chemistry is this. The production and analysis of pharmacological ingredients are additional significant factors. Pharmaceutical chemistry refers to the two latter parts taken together, however some individuals mostly chemists consider the synthesis of pharmaceuticals to be a component of medicinal chemistry, designating analytical aspects as pharmaceutical chemistry.
Pharmaceutical and medicinal chemistry, the literal translations of pharmaceutical and medicinal chemistry, are used interchangeably in German pharmacy schools.
Pharmacy or pharmacology refers to the study of pharmaceuticals in general. Pharmacology is often defined more narrowly to focus on how drugs behave and have an impact on the body. The determination of physiological and pathophysiological factors in body fluids, such as enzyme activity and metabolites in blood and urine, is the focus of clinical chemistry, a distinct field. The study and management of drug substance Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) has been referred to as biopharmacy.
Other concepts that are somewhat interchangeable with medicinal chemistry include drug design, selective toxicity, and (molecular) pharmacochemistry. German terminology for medicinal chemistry includes medicinal/pharmaceutical chemistry and drug discovery, while the French phrase for it is chimie therapeutique. In academic settings, medicinal chemistry is a core subject in the majority of pharmacy faculties, as well as in many chemistry faculties for research and undergraduate students. The pharmaceutical industry's search for new medications is centred on medicinal chemistry.
The goals of medicinal chemistry are simple to state yet challenging to accomplish: Discover, create, and enhance medication compounds that treat or lessen disease and comprehend the underlying and ancillary chemical processes. Physical chemistry, crystallography, spectroscopy, computer based simulation, data analysis, and data visualisation techniques are among the chemistry based disciplines that make up the field of medicinal chemistry. It is situated at the intersection of organic chemistry and the life sciences, including biochemistry, pharmacology, molecular biology, genetics, immunology, pharmacokinetics, and toxicology.