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Marijuana (Cannabis indica)

Shivani Kashyap*

Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India

*Corresponding Author:
Shivani Kashyap
Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India
Tel: +918004774540
E-mail: [email protected]

Received date: 13/09/2016; Revised date: 17/09/2016; Accepted date: 20/09/2016

Visit for more related articles at Research & Reviews: Journal of Chemistry


Compared to any other thing in life people first prefers mental happiness than physical ones. But, those who fail to accomplish or to reach their mental balance levels get into this kind of stuff like marijuana, Ayahuasca, Heroin, Opium or Cocaine like thingies. They are classified under NDPS category i.e., Narcotic Drugs and Psychotropic Substances. They are the substances that are totally prohibited and are illegal. These substances are highly psychoactive and psychotropic in nature.


Cocaine, Narcotic drugs, Psychotropic


In the late 1980s scientists found a receptor for THC and THC-related chemicals in the brains of specific warm blooded animals, including people. This finding demonstrated that the cerebrum normally creates a THC-like substance that may play out a portion of the same capacities that THC does. Such a substance along these lines was found and named anandamide, from "ananda", the Sanskrit word for rapture. At the point when weed is smoked, the blood supply of the lungs retain the THC. The blood then moves to the heart where it builds the heart rate. In the event that the weed is eaten, less THC gets to the cerebrum and takes more time to arrive. The measure of THC in the body would be less for the measure of weed eaten, be that as it may, since it takes more time to work, clients are prone to expend more pot than they would ordinarily smoke. Large amounts of THC can bring about drug like encounters that smokers are less inclined to feel (Figure 1) [1-25].


Figure 1: Synthesis of Marijuana (Cannabis indica).

Effects of Marijuana addiction

• Euphoria.

• Relaxation.

• Drowsiness.

• Altered sense of time.

• Impaired memory.

• Slowed reflexes and impaired motor skills.

• Bloodshot eyes.

• Increased appetite.

• Dry mouth.

• Increased heart rate.

• Cognitive impairments.

• Paranoia


So far as is known right now these isomers have in a general sense the same as quality (weight-for-weight), be that as it may it is likely there may be differentiations in the experience made undifferentiated from the change when hashish is eaten as opposed to smoked. Isomers A and B are found in standard hashish while THC-C is a built THC which has been generally looked into in attempts to set up which parts of the molecule are pivotal to stimulating development (see Adams' papers). With everything taken into account it has been shown that changes of the iota bring about diminishing of activity. Regardless, by changing the alkyl bundle on the right-hand ring (above, n-amyl, made out of five carbon particles in a straight chain) it has been possible to convey THC-C varieties with colossally extended power and term of effect. The variety depicted here as THC-V is at any rate as extreme as LSD (estimation 100-millionths gram) [26-50].

Course of action of five of the most charming of the THC-C analogs differentiating in the alkyl side chain (relegated THC-II, THC-III, THC-IV, THC-V, THC-VI) is delineated in this paper. Note that the looking at alkyl-bundle varieties in the THC-An and THC-B course of action can be organized essentially by adjusting the last development reaction. These materials have not been represented in the written work, yet rather there is inspiration to trust that they have at any rate proportionate activity.

THC-A's can be successfully isomerized-to THC-B's by the method for Mechoulam and Gaoni (J.A.C.S. 90, page 2420, 1968), using p-toluene sulphonic destructive as a piece of verging on quantitative yield [51-75].

The unions of THC-A, THC-B, or THC-C are all in perspective of the development of olivetol (5-(n-amyl)- resorcinol) with a second portion which shapes the left-hand and center ring of the THC molecule. THC-An or THC-B are gotten from olivetol and one of the going with; citral, (-)- verbenol, or (+)- p-2,8-menthadien-2-ol. THC-C is gotten from olivetol and (-)- 2-carbethoxy-5-methylcyclohexane. The varieties in each of the three course of action are procured by supplanting olivetol with a 5-(alkyl)- resorcinol in which the alkyl social event is balanced from n-amyl to one of the going with;

THC: n-amyl

THC-II: n-hexyl

THC-III: 1'- methyl-octyl

THC-IV: 1'- methyl-nonyl

THC-V: 1',2'- dimethyl-heptyl

THC-VI: 1',2'- dimethyl-octyl

The representation given here is for the course of action of 5-(1',2'- dimethyl-heptyl)- resorcinol, the olivetol straightforward required for THC-V. While get prepared THC itself, or the variety THC-II, the union is to some degree shorter, due to the way that the methyl-cluster side chain need not be incorporated [76-100].


Interminable use does not set up physical dependence, nor, upon withdrawal, does the general customer persevere through convincing physical misery, (for instance, that associated with sedatives), however its usage may be rationally habituating. Since THC stays in the body, it has been found to affect the influence scholarly limits (numbering memory) up to 48 hours in the wake of smoking. Regardless, there is no verification that these effects last over two days. Interminable cannabis smokers can experience lung issues and all things considered don't convey as much twist stream as nonsmokers do.


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