Novel Innovations and Formulation Considerations of Oral Dissolving Films

About the Study

Enhanced oral dose forms called oral dissolving films that are intended for adhesion to the buccal mucosa and have both local and systemic effects. Because they are more adaptable and comfortable than conventional oral medication administration methods. These films take advantage of the bio adhesion of certain polymers, which when hydrated target a specific area of the body for a prolonged length of time, avoiding first pass metabolism and enhancing bioavailability. These films are pharmaco-economic, self-administrable, and have high patient compliance. In terms of accessibility, administration and withdrawal, retentively, low enzymatic movement, economy, they provide a wide range of advantages, making them potentially marketable and commercially viable.

Considerations in the development of oral dissolving films

The most preferable buccal films have a surface area of 1 cm² to 3 cm². On average, 10 mg-20 mg of medication can be administered through the buccal mucosa in a single day using a 2 cm2 device. While the delivery system's shape can also change, an ellipsoid form seems to be the most suitable for administering drugs via the buccal route. The delivery device is typically only a few millimeter’s thick. Dissolvable films frequently use aqueous polymer matrixes. Due to their superior performance in a variety of applications, including buccal medication delivery, due to their compatibility with drugs, good film-forming properties, water solubility, safety, and diversity in the molecular weight range. Location of the delivery device is also important to take into account. The ideal buccal film would have an API-loaded layer that adheres to the buccal site directly and erodes at a set rate equal to the time it takes for the entire drug concentration to enter the system. Drug loss in the mouth and gastrointestinal system is kept to minimum recognitions to unidirectional drug release, which guarantees optimal absorption. The maximum time for buccal medicine retention and absorption is about 4 hours to 6 hours because eating or drinking may need removal of the delivery device. The mucus membranes physiology in the presence of disease must be taken into account. Depending on the API, oral mucosal films have a shelf life of 2 years to 3 years; however they are especially vulnerable to moisture in the environment.

New innovations used for oral dissolving films preparation

Wafertabtm: This proprietary drug delivery technology enables the administration of active substances as filmstrips that can be ingested. In this method, a predetermined dosage of the medicine is included into the body of a finished XgelTM film. This preserves the stability of the active substance and guards against overheating and moisture exposure. They are often designed to be ingested or used topically. The medication immediately dissolves when it comes in touch with saliva.

Soluleavestm: This technology keeps the active ingredient in the tongue and is frequently utilized in flavor-release items like vitamins and breath fresheners. These films break down quickly and release the drug into the oral cavity when they come into reach with saliva.

Foambursttm: Soluleaves are a kind of foamed film. In order to develop a honeycombed structure that allows for quick release during filming, an inert gas is pumped inside. This creates a novel mouth feeling that feels somewhat like melting in the mouth.