A Brief Review on Synthesis of Î²-amino Alcohols by Ring Opening of Epoxides
β-amino Alcohols are the versatile intermediates in the preparation of many biologically active compounds as well as in pharmaceutical industry. The synthesis of these structures is achieved by various routes but the simplest way is ring opening of epoxide by an amine. There are several difficulties in making these molecules viz reaction conditions, role of catalyst, stereo effects etc. This review focuses on ring opening of epoxides under different conditions to achieve amino alcohols.
Bhagavathula DS, Boddeti G and Venu R
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