e-ISSN:2320-1215 p-ISSN: 2322-0112

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Research Article Open Access

Challenges of Brain Drug Delivery and G-Technology as One of Solution


Brain is one of the most difficult organ for efficient drug delivery for the treatment of brain related illnesses. The reason behind it the various barriers such as blood brain barrier, blood cerebrospinal fluid barrier and blood tumor barrier present in central nervous system. The blood brain barrier formed by the endothelial cells of the brain capillaries which restricts the entry of most drugs and delivery systems. Blood cerebrospinal fluid barrier and blood tumor barrier also presents a huge problem for effective delivery of therapeutics to the central nervous system (CNS) Therefore, various techniques like BBB disruption , Molecular Trojan Horse Technology, Biology Based Approach, Intranasal Delivery, Stereotactically guided insertion, Chemical Methods, Transporter mediated delivery are being developed to enhance the amount and concentration of therapeutic compounds in the brain. A new method which is called G-Technology also developed to enhance the delivery of drugs.

Shiv K Garg, Abhishek Dwivedi, Pramod Saini, Ajay Pareek, and Sanket Trivedi

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