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Research Article Open Access

Chiral Quantitative Analysis of Loperamide in a State of Acid Degradation by HPLC Method

Abstract

This work describes the stability of Loperamide® hydrochloride in different pH solutions High-Performance Liquid Chromatography (HPLC) is an efficient method of Loperamide® hydrochloride, but the direct analysis procedure is not suitable for the determination of Loperamide® hydrochloride in the presence of its acid degradation product or its impurity. The aim is to develop and validate a new feasible, sensitive and specific analytical procedure using HPLC on chiral columns polysaccharides, namely, CSPsCHIRALCEL OJ-3R, CHIRALCELOD-RH, and CHIRALPACK AD-3R using various mobile phases. According to the results of the chiral separation of Loperamide, for the CHIRALCEL® OJ-3R column, Loperamide is effective compared to the columns CHIRALCEL® OD-RH, CHIRALPACK® AD-3R.

Meriem Bouanini1, Nasser Belboukhari1, Khaled Sekkoum1, Hassan Y Aboul Enein2*, Hakima Fatmi1

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