CHONDROGENESIS: CELLULAR AND MOLECULAR MECHANISMS IN CARTILAGE FORMATION
Chondrogenesis is the biological process through which cartilage is formed from mesenchymal stem cells and plays a vital role in skeletal development, growth plate formation, and tissue repair. It involves a series of coordinated events including mesenchymal cell condensation, differentiation into chondrocytes, extracellular matrix deposition, and hypertrophy. This process is tightly regulated by transcription factors, growth factors, and signaling pathways such as SOX9, TGF-β, and BMP signaling. Understanding the mechanisms of chondrogenesis is essential for developing therapeutic strategies for cartilage-related diseases such as osteoarthritis. This article reviews the stages, molecular regulation, and clinical significance of chondrogenesis.
Rohan Sharma
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