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Clinical and Pathological Characteristics of BRCA2 Positive Breast Cancer in Egyptian Female Patients

Abstract

Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast cancer. Early age at onset is generally considered an indicator of genetic susceptibility to breast cancer. We determined whether tumor pathologic features and clinical features differ in patients with and without BRCA2 mutations, the study was carried out on thirty breast cancer patients, divided as fifteen with familial breast cancer and fifteen with sporadic breast cancer. Seven cases of the familial breast cancer patients showed BRCA2 mutaion. According to this study, there was statistically significant negative correlation between frequency BRCA2 gene mutations and female age, there was negative correlation between BRCA2 gene mutations and ER receptor, PR receptor and HER2/neu status (positivity and negativity) and positive correlation between gene mutations and the pathological grade of the tumor. However, this correlation did not reach a significant level. Three of the seven BRCA2 patients weRe of triple negative molecular type (from total 5patient had triple negative type among the thirty patients). The ER positive BRCA2 patients were mainly luminal B.

Taher Abdel-Aziz , Naglaa Azab , Nashwa M. Emara ,Mosad M. Odah, I.M. El-deen

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