e-ISSN:2320-1215 p-ISSN: 2322-0112

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article Open Access

Formulation and Development of In Situ Gelling System for Nasal Administration for Ondansetron Hydrochloride by Using Pluronic F-127


In the recent years one of the big problems with cancer chemotherapy is cancer induced nausea and vomiting (CINV). In the treatment of CINV the use of 5HT3 receptor antagonist is most popular. One of such 5HT3 antagonist is Ondansetron Hydrochloride. But Ondansetron has a low oral bioavailability along with a patient suffering from vomiting problem it is difficult to deliver the drug through oral route. So our objective is to prepare a in situ nasal gel of the Ondansetron using PF-127 as the thermoreversible polymer. We used HPMC E15 and Chitosan as the mucoadhesive polymer to increase the nasal residence time of the formulation. To increase the permeation we used Polyethylene Glycol 400 and Propylene glycol as the permeation enhancer.

Anjan De, Subrata Chakraborty, Arup Mukherjee and Jayanta Chattopadhyay

To read the full article Download Full Article | Visit Full Article

cappadocia hotels
cappadocia hotel
cappadocia balloon
cappadocia balloon flights