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Improve the Dissolution Rate of Dolutegravir Tablets by Solid Dispersion Method
The present study was carried out on dolutegravir by employing solid dispersion technique. The λmax of phosphate buffer pH 6.8 of dolutegravir were found to be at 334 nm. The pure drug the optimised solid dispersion formulations were subjected to FTIR studies. The results were showed that there is no interaction between the drug and excipients. The micrometric properties of blend of dolutegravir soild dispersion were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. Angle of repose was less than 280, Carr’s index values were 10 to 17 for the pre compression blend of all the batches indicating good to fair flowability and compressibility. Hausner’s ratio was less than 1.2 for all the batches indicating good flow properties. All the tablets of different batches complied with the official requirement of weight variation as their weight variation passes the limits. The hardness of the tablets ranged from 2 to 3 kg/cm2 and the friability values were less than 1% indicating that the tablets were compact and hard. The thickness of the tablets ranged between 3.1 to 3.8 mm. All the formulations satisfied the content of the drug as they contained 96%-100% of dolutegravir and good uniformity in drug content was observed. Thus all the physical attributes of the prepared tablets were found to be practically within control limits. The dissolution profile of dolutegravir tablets were compared between solid dispersion tablets. The dolutegravir solid dispersion tablets showed better release in phosphate buffer pH 6.8, in that F2 showed good drug release i.e., 99.89 at 15 minutes. F2 formulation was taken as optimised formulation.