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Manganese Induced Hematological Alterations in Albino Rats: Reversal Effect of Alpha- Tocopherol

Abstract

Manganese (Mn) is a mineral element is nutritionally essential and potentially toxic to biological tissues. Due to pollution Mn level is potential in environment. In the present study Albino rats were exposed to manganese and α- tocopherol to observe the possible interactions. Albino rats of two months and four months were exposed to Mn by intraperitoneal injections dissolved form of Manganese sulphate (MnSo4). α- tocopherol was given to the Mn exposed rats through intraperitoneal injections (30mg/Kg bw). Rats were randomly divided into five groups with different treatments such as Controls, Low Mn exposure (2.5 mg/kg bw), Low dose of Mn exposure along with α- tocopherol, High dose of Mn exposure(5mg/kg bw), High dose of Mn exposure along with α- tocopherol in two different age groups two months and four months. Hematological changes were observed after Mn exposure. In this study, we have examined that the red blood cells, white blood cells, hemoglobin, packed cell volume, serum urea, serum creatinine, serum cholesterol, serum bilirubin. Hematological changes in low and high dose of Mn exposure showed decrease in Red blood cells, hemoglobin, packed cell volume and increase in white blood cells, serum urea, serum bilirubin, serum creatinine, and serum cholesterol in dose dependent manner. α- tocopherol is considered the most effective liposolouble antioxidant. However, the animals which received α- tocopherol with low and high dose of Mn showed recovery. The two months rats showed more susceptibility to Mn and also showed more recovery with α- tocopherol when compared to four months rats.

Indravathi.G, Kiran Kumari.K, Bhuvaneswari Devi.C

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