Commentary Open Access

Possibility of Using the Interferon Gamma Release Level As a Dynamic Biomarker

Abstract

 The potential of using interferon-γ (IFN-γ) release as a biomarker was examined in the previous study. Twenty-nine patients treated with immune checkpoint inhibitors were divided into three groups according to their IFN-γ release level in the positive control after enzyme-linked immunosorbent assay. The three groups showed clear differences in clinical outcomes. IGR can be a new dynamic biomarker to determine the immunological status of a patient at the pretreatment stage or any change in the state of their immunity during the treatment of various diseases.

 Tomonori Hirashima, Hidekazu Suzuki, TomohiroKanai, Hiroko Yoshida, Yoshitaka Tamura, Norio Okamoto,Toshio Tanaka

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