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Short Note on Magnetic Targeting of Nanoparticles


Magnetic Nanoparticles (MNPs) have shown extraordinary potential as Nano-Transporters for proficient BBB crossing under the outer Static Magnetic Field (SMF). To evaluate the effect of SMF on MNPs' in vivo elements towards BBB crossing, we fostered a Physiologically Based Pharmacokinetic (PBPK) model for Intraperitoneal (IP) infused superparamagnetic iron oxide nanoparticles covered by gold and formed with Poly Ethylene Glycol (PEG) (SPIO-Au-PEG NPs) in mice. Unlike most reported PBPK models that ignore brain permeability, we first obtained the brain permeabilities with and without SMF by determining the concentration of SPIO-Au-PEG NPs in the cerebral blood and brain tissue. This focus in the mind was reproduced by the shift in weather conditions dispersion conditions and was mathematically tackled in COMSOL Multiphysics. The outcomes from the PBPK model in the wake of consolidating the cerebrum penetrability showed a decent understanding with the in vivo outcomes, checking the capacity of utilizing the proposed PBPK model to foresee the in vivo biodistribution of SPIO-Au-PEG NPs under the openness to SMF.

Fabio Benfenati

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