Strategies for Effective Oral Insulin Delivery with Protamine Coated Proliposomes Encased in Eudragit S100 Coated Capsule: A Review
Parenteral administration of insulin is associated with serious flaws like potential pain or discomfort for the patient, local allergy, abscess at the injection site, lipoatrophy (localized loss of fat tissue) and anaphylaxis. In addition, industrial issues like physical and chemical changes during manufacturing, shipping, storage and administration also influence the clinical potency of insulin. Hence, proliposomes followed by encasing in eudragit S100 coated capsule for oral administration has been widely studied in oral insulin delivery to address pharmaceutical, physiological and industrial issues. This review focuses on advancement in the synthesis of protamine coated proliposomes of recombinant human insulin encased in Eudragit S100 coated capsule for efficient oral insulin delivery. Alterations to protect insulin from the cruel acidic environment of the gastro-intestinal (GI) tract are defined. Chemical barriers for example, the acidic gastric pH and the presence of proteolytic enzymes in the stomach and intestine restrain the effective absorption of external insulin within the GI tract.