Study of Antimicrobial Quinolones and Structure Activity Relationship of Anti-Tubercular Compounds
Fluoroquinolones (FQs) are an important synthetic antimicrobial agents being clinically used. Currently some FQs are under investigation for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensive drug resistance (XDR-TB) and are under investigation as first-line drugs. Their main biological target in Mycobacterium tuberculosis is the DNA gyrase, a topoisomerase II encoded by gyrA and gyrB that is essential to maintain the DNA supercoil. The mutations in short regions of DNA gyrase are associated with quinolone resistance or hyper susceptibility and take place in several MDR clinical isolates of M. tuberculosis. The anti-TB property mode of action and structure activity relationship studies of the some known quinolone derivatives are studied. Furthermore, the activity of quinolones as new class of potent and selective anti-TB agents, particularly their activity against MDR-TB and XDR-TB.