e-ISSN: 2319-9849

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article Open Access

Synthesis and Anti-inflammatory Evaluation of 1,2,4 Triazole Derivatives


A mixture of 4-hydroxyphenylacetic acid, absolute ethanol, few drops of concentrated sulphuric acid along with a small porcelain chip on reaction formed Ethyl-(4-hydroxyphenyl) acetate (1). On condensing mixture of (1), hydrazine hydrate and absolute ethanol formed 4-Hydroxyphenyl acetic acid hydrazide (2). Further mixture of 2, aryl/alkyl isothiocyanate and ethanol was refluxed and formed N1-[2-(4-Hydroxyphenyl) acetyl] N4-alkyl/aryl-3-thiosemicarbazide (3a-i). A suspension of (3a-3i) in ethanol, sodium hydroxide is refluxed for 2 hours on a water bath and formed 5-(Hydroxyphenyl) methyl-4-alkyl/aryl-2-mercpto-1,2,4(H)-triazoles (4a-i). The 1,2,4-triazole derivatives of 4-hydroxyphenyl acetic acid (4a-i) showed anti-inflammatory activity and Ibuprofen was taken as the standard drug

Meenakshi Virmani, Sabir Hussain

To read the full article Download Full Article | Visit Full Article

Replica watches