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Research Article Open Access

Synthesis, Characterization and Biological Studies of Novel 1,3,4-Oxadiazole Derivatives


Naphtho[2,1-b]furan-2-carbohydrazide (2) prepared from reaction between ethyl naphtho[2,1-b]furan-2-carboxylate (1) and hydrazine hydrate, then compound (2) on reaction with CS2/KOH gives 5-(naphtho[2,1-b] furan-2-yl)-1,3,4-oxadiazole-2(3H)-thione (3), Which on mannich reaction followed by reaction with benzoic hydrazine gives different N-(1- ((dialkylamino)methyl)-3-(naphtho[2,1-b]furan-2-yl)-5-thioxo-1H-1,2,4- triazol-4(5H)-yl)benzamide (4a-e). With the help of analytical and spectral data, the structure of these compounds were detected. Antibacterial and antifungal activities of the synthesized compounds were studied

Darshansinh AR, Acharya GD and Govindkumar RV

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