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**Adebara Lanre ^{*}**

Department of Mathematics and Statistics, Federal Polytechnic, Ado-Ekiti, Nigeria

- *Corresponding Author:
- Adebara Lanre

Department of Mathematics and Statistics

Federal Polytechnic, Ado-Ekiti, Nigeria

**E-mail:**lanreadebara@gmail.com

**Received Date:** 29/11/2017 **Accepted Date:** 01/02/2018 **Published Date:** 05/02/2018

**Visit for more related articles at** Research & Reviews: Journal of Statistics and Mathematical Sciences

Crossover design is found several field such pharmaceutical industry, agricultural field with the presence of carryover effects of treatment in the present period of treatment application from proceeding period. In this paper, we reviewed method of construction of incomplete sequence balanced crossover design given Patterson and Lucas.

Crossover, Sequence, Carryover, Incomplete.

Crossover design is an experiment in which subject (sequence) are exposed to different treatment at different time period. The subject can be animals or plots of land. This design has been used in many areas such as clinical trials, agricultural experiments, and etc. William’s square for more than two treatments was given by Williams [1] using row and column approaches for the number of treatment v is even or odd.

Hedayat and Min Yang [2] used William’s method of construction for more than two treatments column method approach to
develop their method of construction called balanced uniform crossover designs in which they used the same procedure given by
Williams [1] with the only difference is that of repeating the last row of a William’s square once. Some of authors that have developed
method of construction for incomplete crossover designs are Kanchan and Rumana [3] developed method for an incomplete
block change-over balanced for first and second-order residual effect, Mithilesh and Archana [4] gave method of construction for
balanced incomplete sequence crossover design for first order residual effect, and Patterson and Lucas [5] discussed method of
construction for incomplete sequence balanced crossover designs. However, we shall review that of Patterson and Lucas [5] that
used William’s method of construction for more than two treatments column method approach to construction incomplete ssequence
balanced crossover designs as shown in ** Tables 1-4**.

Period | 1 | 2 | 3 | 4 |
---|---|---|---|---|

1 | 1 | 2 | 3 | 0 |

2 | 0 | 1 | 2 | 3 |

3 | 2 | 3 | 0 | 1 |

4 | 3 | 0 | 1 | 2 |

**Table 1.** For the number of treatments, v = 4.

Period | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
---|---|---|---|---|---|---|---|---|---|---|

1 | 1 | 2 | 3 | 4 | 0 | 2 | 3 | 4 | 0 | 1 |

2 | 0 | 1 | 2 | 3 | 4 | 3 | 4 | 0 | 1 | 2 |

3 | 2 | 3 | 4 | 0 | 1 | 1 | 2 | 3 | 4 | 0 |

4 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 |

5 | 3 | 4 | 0 | 1 | 2 | 0 | 1 | 2 | 3 | 4 |

**Table 2.** For the number of treatments, v=5

Period | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|

1 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 5 | 1 | 2 | 4 | 5 | 1 | 3 | 4 | 5 | 2 | 3 | 4 | 5 |

2 | 4 | 1 | 2 | 3 | 5 | 1 | 2 | 3 | 5 | 1 | 2 | 4 | 5 | 1 | 3 | 4 | 5 | 2 | 3 | 4 |

3 | 2 | 3 | 4 | 1 | 2 | 3 | 5 | 1 | 2 | 4 | 5 | 1 | 3 | 4 | 5 | 1 | 3 | 4 | 5 | 2 |

4 | 3 | 4 | 1 | 2 | 3 | 5 | 1 | 2 | 4 | 5 | 1 | 2 | 4 | 5 | 1 | 2 | 4 | 5 | 2 | 3 |

**Table 3.** Experimental units.

PERIOD PERIOD | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|

1 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 4 | 1 | 2 | 4 | 2 | 3 | 4 | 2 | 3 | 4 | 1 | 3 | 4 | 1 | 3 | 4 |

2 | 3 | 1 | 2 | 2 | 3 | 1 | 4 | 1 | 2 | 2 | 4 | 1 | 4 | 2 | 3 | 3 | 4 | 2 | 4 | 1 | 3 | 3 | 4 | 1 |

3 | 2 | 3 | 1 | 3 | 1 | 2 | 2 | 4 | 1 | 4 | 1 | 2 | 3 | 4 | 2 | 4 | 2 | 3 | 3 | 4 | 1 | 4 | 1 | 3 |

**Table 4.** Experimental units.

**Method of Construction of Balanced Crossover Design for more than Two Treatments Column Method Approach**

For constructing a balanced CODs for v treatment in v sequences and v periods for number of v is even given by William [1]

**For number of treatments, v is even**

For sequence 1 treatment will be

i)1, 2,…, V/2 occur in the periods 1, 3,…, V-1 respectively

ii)V/2 + 1, V/2 + 2, …, V occur in the periods V, V-2,…, 2 respectively

(iii) The assignments for sequences 2, 3, V are obtained through a cyclic development of the arrangement for sequence 1

**For number of treatments, v is odd**

For sequence 1 the treatment will be

1, 2, …, (V+1)/2 occur in periods 1,3, …, v respectively

(V+1)/2+1, (V+1)/2 + 2 ,…, V occur in periods V-1, V-3,…,2 respectively

The assignment for sequences 2, 3, V are obtained through a cyclic development of the arrangement for sequence 1.

The arrangement for sequence (V+1) is the mirror image sequence V

**Method of Construction for Incomplete Sequence Balanced Crossover Designs**

Consider block contents of each of the block of the Balanced Incomplete Block Design.

Take the first block and construct Williams’s squares for the treatment in that block [5]

**Example 1: **For 5 treatments and block size 4, we consider the following BIBD with parameter (5, 5, 4, 4, 3)

1 | 2 | 3 | 4 |

1 | 2 | 3 | 5 |

1 | 2 | 4 | 5 |

1 | 3 | 4 | 5 |

2 | 3 | 4 | 5 |

The incomplete sequence balanced crossover design formed by using the block contents of this BIB design through balanced crossover design for more than two treatments column method approach for number of treatment v is odd. Thus we get incomplete sequence balanced crossover design with v=5, p=4 and n=20

**Example 2: **For 4 treatments and block size 3, we consider the following BIBD with parameter (4, 4, 3, 3, 2)

1 | 2 | 3 |

1 | 2 | 4 |

2 | 3 | 4 |

3 | 4 | 1 |

The incomplete sequence balanced crossover design formed by using the block contents of this BIB design through balanced crossover design for more than two treatments column method approach for number of treatment v is even.

Thus we get incomplete sequence balanced crossover design with v=4, p=3 and n=24.

It was discovered that we can obtain incomplete sequence from balanced incomplete block design in which number of period is less than that of experimental units and also the number of experimental units double the number of treatment when block sizes is odd.

We therefore conclude that Patterson and Lucas method of construction for incomplete sequence balanced crossover designs is easier and straight forward to use than other methods of incomplete sequence crossover design.

- Williams EJ. Experimental designs balanced for the estimation of residual effect treatment. Australian Journal of Scientific Research. 1949;2:149-168.
- Hedayat AS and Yang M. Universal optimality of balanced uniform crossover designs. The Annals of Statistics. 2003;31:978-983.
- Kanchan C and Rumana R. An Incomplete block change-over design balanced for first and second-order residual effect. 2013.
- Mihilesh K and Archana V. Construction of some new optimal cross-over designs of first order. International Journal of Mathematical Archive. 2015;6:187-192.
- Patterson HD and Lucas HL. Change-over designs. North Carolina Agricultural Experiment Station Tech. Bull. 1962;147.