ISSN: 2319-9865

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Correlation of the various clinical Findings and chief complains with histopathological pattern of endometrium Biopsies: A study of 300 cases

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Abstract

Abnormal uterine bleeding and infertility are among the commonest conditions for which patients seek advice in the gynecological outpatient department.Endometrial biopsy is currently the most commonly used technique for histological evaluation of endometrial pathology. The study was aimed to find the incidence of various pathological lesions of endometrium i.e non-neoplastic as well as neoplastic and to correlate various clinical findings like age, chief complaints, and duration of these complaints with histopathological features. The present study included 300 endometrial biopsies with clinical diagnosis of Dysfunctional uterine bleeding or infertility, received in the Department of Pathology, Government Medical College, Patiala. The biopsies were processed and sections stained with H and E stain. Special stain (ZiehlNeelsen) was done wherever necessary. Primary infertility (75%) is more common than secondary infertility (25%). Most common presenting age group for DUB cases was 41-50 years (40.91%) and for infertile cases, 26-30 years (47.5%). The most common type of bleeding in DUB cases was menorrhagia (47.73%). Proliferative endometrium (30.45%) was the most common endometrial pattern in DUB cases and secretory endometrium (35%) in infertility cases. Benign neoplasms (endometrial polyp) constituted 3.64% of DUB cases and premalignant conditions (hyperplastic endometrium)-16.36% of DUB cases. Malignant neoplasms (endometrial carcinoma) were found in 3.64% of DUB cases, being most common in 6th decade of life (50%) and postmenopausal bleeding (62.5%) was the most common clinical presentation.