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Biological Effects of an Aqueous Extract of Phthirusa pyrifolia (Kunth) Eichler Leaves

Abstract

Phthirusa pyrifolia (Kunth) Eichler is claimed in medicinal practice in Brazil, to be useful in the treatment of respiratory diseases and liver injury, aphrodisiac effect, and also for to its antimicrobial properties, and is also used in Peru to treat fractures and sprains. The aim of this research was to evaluate the effects of an aqueous extract from P. pyrifolia leaves in male rats submitted to oral administration. Animals in experimental protocol were submitted to natural oral ingestion of P. pyrifolia leaves aqueous extract over to 12 days. Total blood aliquots were collected for hormonal and biochemical-hematological analysis. After the treatment period, the rats were subcutaneously anesthetized, euthanized and afterwards orchidectomized. The biochemical parameters revealed a significant decrease in aspartate-aminotransferase, alanineaminotransferase and alkaline-phosphatase enzyme levels by about 40%, 27% and 52%, respectively. However, the extract does not cause liver injury and no impairment of renal function as well no affect any hematological parameters, but the histological analysis revealed a somatic action on the testes. The testosterone hormone levels of treated rats were drastically affected and showed a higher decrease (p<0.05) of about 82.31% than compared with the control, 46.0 (± 8.1) ng/dL and 260.0 (±4.1) ng/dL, respectively. We believe that the aqueous extract may be responsible to promote a decrease in the libido and reproduction in male rats, and induces hepatic-protective effects. Our results contribute towards validation of the traditional use of the plant.

Romero M.P.B. Costa, Vivianne Ferreira Araujo, Antônio F.M. Vaz, Elizabeth S. Neves, Maria T.S. Correia, Maria G. Carneiro-da-Cunha

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