The Effects of the Novel Herbal Drug Gamijakyakgamchobuja-Tang (KCHO-1) on Neuropathic Pain in Mice
Neuropathic pain is caused by damage or disease in the nervous system. In neuropathic pain, inhibitory GABAergic neurons are destroyed, and excitatory neurons are hyperactivated. In this study, we showed that the novel herbal drug Gamijakyakgamchobuja-tang (KCHO-1) can effectively reduce neuropathic pain. In the spinal nerve ligation (SNL) model, neuropathic pain results from the loss of neurons utilizing γ-aminobutyric acid (GABA) and the generation of reactive oxygen species (ROS) in the injured spinal cord. Treatment of SNL mice with KCHO-1 had an anti-oxidative effect, reducing ROS generation, and also induced the regeneration of GABAergic neurons in injured tissue. These data suggest that KCHO-1 may be a potential therapeutic drug for the treatment of neuropathic pain.
Minjun Ji, Do Ho Kim, Dong Woung Kim, Bong Keun Song, Ilhong Son, Kwang won Seo, Jiwoong Kim, Sungchul Kim and Kyung-sun Kang