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Volume 5, Issue 5 Res. Rev. J Mat. Sci. 2017
ISSN: 2321-6212 Advanced Materials 2017
September 07-08, 2017
September 07-08, 2017 | Edinburgh, Scotland
Advanced materials & Processing
11th International Conference on
Interaction of nanoparticles with amino acids and a physiologically important model protein studied by
spectroscopic techniques
Karolína M. Šišková
Palacký University in Olomouc, Czech Republic
Nanoparticles (NPs) are currently the topic of interest of a bundle of research papers and proposals. There are persistent rumors
about NPs toxicity and ecotoxicity, concerns about their increasing release into the environment and attempts to their risk
assessment. Many researchers often test the impact of different kinds of NPs on cells, tissues, organs, and/or directly on whole
organisms. However, in order to understand the possible NPs impacts it is necessary, in my opinion, at first to evaluate the interaction
of NPs with one type of the basic units of all organisms and their cells, i.e. amino acids. Furthermore, it is important to elucidate
whether and how can NPs affect the conformation of proteins (their secondary and tertiary structure). Only after gaining such
information, the assessment of NPs toxicity and ecotoxicity could be meaningful. In this study, the interaction of synthesized and
commercially available nanoparticles with selected amino acids and a physiologically important transmembrane protein, the sodium/
potassium pump (Na+/K+-ATPase) will be investigated by using several spectroscopic techniques. The sodium/potassium pump is
an enzyme which is ubiquitous in all animal cells and its malfunctions are related to many diseases such as hypertension, diabetic
neuropathies, renal failure, neurological disorders etc.
Biography
Karolína M. Šišková has her expertise in nanoparticle synthesis, characterization, application and in vibrational spectroscopy. She published more than 40 papers
as the main author or co-author in impacted scientific journals and presented more than 20 oral contributions and 8 posters on different nanomaterial and
spectroscopic conferences and meetings. She graduated in physical chemistry from the Charles University in Prague and in INTER///BIO from the Université Pierre
et Marie Curie, Paris VI, in 2006. In 2014, she was awarded the conferment of associate professor degree in physical chemistry. Her h-index is 15 and the number
of citations 515 (without self-citations) according to the Web of Science on 20th December 2016. Coming back from her maternity leave in September 2016, she
started to work at the Department of Biophysics, Faculty of Science, Palacký University in Olomouc, Czech Republic.
Karolína M. Šišková et al., Res. Rev. J Mat. Sci. 2017, 5:5
DOI: 10.4172/2321-6212-C1-005