emerging-materials-2017-posters-accepted-abstracts

17 / 18

Page 89
conferenceseries.com
RRJOMS | Volume 5 | Issue 4 | July, 2017
July 27-29, 2017 Vancouver, Canada
10th International Conference on
Emerging Materials and Nanotechnology
Res. Rev. J Mat. Sci. 2017
DOI: 10.4172/2321-6212-C1-003
Multifunctional nanoparticles composed of a mixed ferrite core and a mesoporous silica shell for RGD
peptide to target α (v) β (3) integrin in cancer therapy and diagnosis
Susel Del Sol Fernandez1, Herlys Viltres Cobas1, Oscar F Odio Chacon 2, Ricardo García Salcedo 1 and Edilso Reguera Ruiz1
1Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Mexico
2Instituto de Ciencia y Tecnología de Materiales, Cuba
The integrin αvβ3 plays an important role in angiogenesis. It is expressed on tumor endothelial cells as well as on some
tumor cells. RGD peptides are well-known to bind preferentially to the αvβ3 integrin. In this context, targeting tumor
cells or tumor vasculature by RGD-based strategies is a promising approach for delivering anticancer drugs or contrast
agents for cancer therapy and diagnosis. A key challenge in developing theranostic nanoplatform is to achieve an optimal
pharmacokinetic profile to allow sufficient targeting and to avoid rapid clearance by the reticuloendothelial system (RES).
Recently, multifunctional nanostructured materials have been applied to multimodal imaging and simultaneous diagnosis
and therapy. In this context, the integration of mesoporous silica with superparamagnetic monodisperse nanocrystals to form
uniform core–shell composite particles has great potential for simultaneous bioimaging and drug delivery. In the present study,
mixed ferrite (MnFe2O4) were coated with a mesoporous silica and polyethylene glycol (PEG), making them water soluble
and function-extendable for future bioconjugation with RGD peptide. MnFe2O4@mSiO2-PEG particles were characterized
by DRX, TEM, DLS and VMS. Results showed that a spherical, highly-ordered MnFe2O4 nanoparticles with a diameter of
around 10 nm, and a narrow size distribution. Dynamic light scattering (DLS) analysis revealed that such MnFe2O4@mSiO2-
PEG has a hydrodynamic size of ˜20 nm in aqueous solution. The field dependent magnetism of 300 K shows no hysteresis,
demonstrating a superparamagnetic behavior, which is a desirable characteristic for T2 MR contrast agents. The integrated
capability of the core–shell NPs to be used as MR and fluorescence imaging agents, along with their potential use as a drug
delivery vehicle, make them a novel candidate for future cancer diagnosis and therapy
Effect of carbonization and multi-walled carbon nanotubes on polyacrylonitrile short carbon fiber
polymer composites
Vijay Kumar Srivastava
Indian Institute of Technology, India
The present work deals with the characterization of multi-walled carbon nanotubes (MWCNTs) filled and unfilled short
carbon fibre reinforced epoxy resin composites. Short carbon fibres (10 mm) were selected at various processing stages such
as i) white colour polyacrylontrile fibres (PAN), ii) pre-carbonized carbon fibres (precarbonized CF), iii) oxidized carbon fibres
(OPF), iv) fully carbonized carbon fibres (CF-low) and v) sized carbon fibres (CF Sized). The investigated composites were
characterized by three points bending test, hardness test, dynamic mechanical thermal analysis, electrical conductivity test,
thermogravimetric analysis and scanning electron microscopy. The results show that the mechanical and electrical properties
of the investigated materials markedly depend on the type of short carbon fibres and on the presence of MWCNTs