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conferenceseries
.com
November 13-15, 2017 | Las Vegas, USA
14
th
International Conference and Exhibition on
Materials Science and Engineering
RRJOMS | Volume 5 | Issue 7 | November, 2017
Fatty acid-based electrospun fiber for temperature-controlled drug release
Ji Hyeon Choi, Se Jeong Hwang, Hyun Jin Oh, Dong Gug Kang
and
Dong Choon Hyun
Kyungpook National University, Republic of Korea
T
his paper explains fatty acid-based electrospun fibers for temperature-controlled drug release. The polymer fibers have core-
sheath structure. Rhodamine B-loaded polymer particles are enclosed in the core while the sheath contains biodegradable
polymer and mixture of fatty acids. The mixture consists of two fatty acids with different melting points. At a specific composition,
the mixture represents a single melting point 38-40
t
C which is slightly higher the normal human body temperature. This controllable
melting of the mixture allows the temperature-regulated release of the dye from the fibers. Below its melting point, the mixture of fatty
acids incorporated into the sheath will be in a solid state to restrict the passing of the dye molecules pre-loaded in the core whereas the
molecules can be released instantly through the pores over the melting point. The release profiles of the dye molecules can be further
manipulated by varying the amount of the mixture contained in the fibers.
Biography
Ji Hyeon Choi is a first year master course student in polymer science and engineering at Kyungpook national university in Republic of Korea under professor Dong Choon
Hyun. She received her B.S. degree in polymer science and engineering from the same university..
jode1532@naver.comJi Hyeon Choi et al., Res. Rev. J Mat. Sci. 2017, 5:7
DOI: 10.4172/2321-6212-C1-012